Double-blind, randomized crossover study of intravenous infusion of magnesium sulfate versus 5% dextrose on depressive symptoms in adults with treatment-resistant depression

Syed M A Mehdi, Steven E. Atlas, Sidra Qadir, Dominique Musselman, Sharon Goldberg, Judi Woolger, Raul Corredor, Muhammad H. Abbas, Leopoldo Arosemena, Simone Caccamo, Carmen S G Campbell, Ashar Farooqi, Jinrun Gao, Janet Konefal, Lucas C. Lages, Laura Lantigua, Johanna Lopez, Vanessa Padilla, Ammar Rasul, Anna M. RayHerbert G. Simões, Eduard Tiozzo, John E Lewis

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Aim: Treatment-resistant depression patients are more likely to suffer from comorbid physical and mental disorders, experience marked and protracted functional impairment, and incur higher health-care costs than non-affected individuals. Magnesium sulfate is a treatment option that may offer great potential for patients with treatment-resistant depression based on prior work in animals and humans. Methods: Twelve subjects with mild or moderate treatment-resistant depression were randomized into a double-blind crossover trial to receive an infusion of 4g of magnesium sulfate in 5% dextrose or placebo infusion of 5% dextrose with a 5-day washout in between the 8-day intervention period. Subjects were assessed before and after the intervention for serum and urine magnesium, lipid panel, the Hamilton Rating Scale for Depression, and the Patient Health Questionnaire-9. Results: We found a difference in serum magnesium from day 2 to 8 (pre-infusion) (P< 0.002) and from baseline to day 8 (P< 0.02). No changes were noted on the Hamilton Rating Scale for Depression or the Patient Health Questionnaire-9 24h post-treatment, but as serum magnesium increased from baseline to day 7, the Patient Health Questionnaire-9 decreased from baseline to day 7 (P=0.02). Conclusion: Magnesium sulfate did not significantly affect depression 24h post-infusion, but other results were consistent with the literature. The association between changes in serum magnesium and the Patient Health Questionnaire-9 supports the idea that magnesium sulfate may be used to address treatment-resistant depression, an ongoing medical challenge.

Original languageEnglish (US)
JournalPsychiatry and Clinical Neurosciences
DOIs
StateAccepted/In press - 2016

Keywords

  • Depressive symptoms
  • Intervention study
  • Intravenous infusions
  • Magnesium sulfate
  • Treatment-resistant depression

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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    Mehdi, S. M. A., Atlas, S. E., Qadir, S., Musselman, D., Goldberg, S., Woolger, J., Corredor, R., Abbas, M. H., Arosemena, L., Caccamo, S., Campbell, C. S. G., Farooqi, A., Gao, J., Konefal, J., Lages, L. C., Lantigua, L., Lopez, J., Padilla, V., Rasul, A., ... Lewis, J. E. (Accepted/In press). Double-blind, randomized crossover study of intravenous infusion of magnesium sulfate versus 5% dextrose on depressive symptoms in adults with treatment-resistant depression. Psychiatry and Clinical Neurosciences. https://doi.org/10.1111/pcn.12480