Double-blind Controlled Trial of a Micronized Preparation of Flumedroxone (Demigran) in Prophylaxis of Migraine

W. G. Bradley, P. Hudgson, J. B. Foster, D. J. Newell

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A double-blind cross-over trial of a micronized preparation of flumedroxone an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine. No benefit was found in males, or in females with no history of menstrual exacerbation of migraine. In women whose migraine was worse around the time of menstruation fiumedroxone resulted in statistically fewer headaches of less severity. With the dose used in this trial (micronized flumedroxone 10 mg. t.d.s.) side-effects were frequent, the commonest being polymenorrhagia, which occurred in half the women of reproductive age.

Original languageEnglish (US)
Pages (from-to)531-533
Number of pages3
JournalBritish medical journal
Volume3
Issue number5617
DOIs
StatePublished - Aug 31 1968

ASJC Scopus subject areas

  • Medicine(all)

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