Dosimetric evaluation of MRI-based treatment planning for prostate cancer

Lili Chen, R. A. Price, T. B. Nguyen, L. Wang, J. S. Li, L. Qin, M. Ding, E. Palacio, C. M. Ma, A. Pollack

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

The purpose of this study is to evaluate the dosimetric accuracy of MRI-based treatment planning for prostate cancer using a commercial radiotherapy treatment planning system. Three-dimensional conformal plans for 15 prostate patients were generated using the AcQPlan system. For each patient, dose distributions were calculated using patient CT data with and without heterogeneity correction, and using patient MRI data without heterogeneity correction. MR images were post-processed using the gradient distortion correction (GDC) software. The distortion corrected MR images were fused to the corresponding CT for each patient for target and structure delineation. The femoral heads were delineated based on CT. Other anatomic structures relevant to the treatment (i.e., prostate, seminal vesicles, lymph notes, rectum and bladder) were delineated based on MRI. The external contours were drawn separately on CT and MRI. The same internal contours were used in the dose calculation using CT- and MRI-based geometries by directly transferring them between MRI and CT as needed. Treatment plans were evaluated based on maximum dose, isodose distributions and dose-volume histograms. The results confirm previous investigations that there is no clinically significant dose difference between CT-based prostate plans with and without heterogeneity correction. The difference in the target dose between CT- and MRI-based plans using homogeneous geometry was within 2.5%. Our results suggest that MRI-based treatment planning is suitable for radiotherapy of prostate cancer.

Original languageEnglish (US)
Pages (from-to)5157-5170
Number of pages14
JournalPhysics in Medicine and Biology
Volume49
Issue number22
DOIs
StatePublished - Nov 21 2004
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Chen, L., Price, R. A., Nguyen, T. B., Wang, L., Li, J. S., Qin, L., Ding, M., Palacio, E., Ma, C. M., & Pollack, A. (2004). Dosimetric evaluation of MRI-based treatment planning for prostate cancer. Physics in Medicine and Biology, 49(22), 5157-5170. https://doi.org/10.1088/0031-9155/49/22/010