Dose volume histogram analysis of the Gamma Knife radiosurgery treating twenty-five metastatic intracranial tumors

C. C J Yang, J. Ting, X. Wu, Arnold Markoe

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Treating multiple brain metastatic sites in Gamma Knife radiosurgery is not uncommon. Most metastases can be treated with few or even one single shot. Occasionally we have patients returning for retreatment for different intracranial metastatic sites at different times. Dose distribution for these metastases are prescribed locally without considering the previous dose contribution. We present a study which simultaneously calculates the dose distribution of 25 randomly placed shots distributed inside the intracranial region. The Dose Volume Histogram (DVH) is plotted to study the coverage of the tumor sites and normal tissues. We have calculated ten DVH studies and show that 50% of the brain volume receives less than 500 cGy for the maximum tumor dose of 40 Gy, and the dose gradient is extremely steep. This DVH analysis shows that the Gamma Knife radiosurgery is a good treatment modality to control the local tumors while maintaining normal brain function, even for the large number of brain metastasis treated at different times.

Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalStereotactic and Functional Neurosurgery
Volume70
Issue numberSUPPL. 1
DOIs
StatePublished - Nov 2 1998

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Radiosurgery
Brain
Neoplasm Metastasis
Neoplasms
Retreatment
Therapeutics

Keywords

  • Dose Volume Histogram (DVH)
  • Gamma Knife
  • Intracranial tumor
  • Radiosurgery

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Dose volume histogram analysis of the Gamma Knife radiosurgery treating twenty-five metastatic intracranial tumors. / Yang, C. C J; Ting, J.; Wu, X.; Markoe, Arnold.

In: Stereotactic and Functional Neurosurgery, Vol. 70, No. SUPPL. 1, 02.11.1998, p. 41-49.

Research output: Contribution to journalArticle

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