Dose response to chlorthalidone in patients with mild hypertension. Efficacy of a lower dose

Barry J. Materson, James R. Oster, Ulrich F. Michael, Sanford M. Bolton, Zeb C. Burton, John E. Stambaugh, John Morledge

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

A multicenter study of chlorthalidone was performed to determine the relative antihypertensive efficacy and side effects of doses lower than those usually recommended for therapy. After a 4-wk placebo control period 100 patients with mild hypertension were randomly assigned doubleblind to 12.5-, 25-, 50-, or 75-mg regimens of chlorthalidone or to placebo for 12 wk. The groups of patients taking 25, 50, and 75 mg had declines in blood pressure which were not significantly different from each other. Serum potassium decreased in the 50- and 75-mg groups but not significantly in the 25-mg group. We conclude that chlorthalidone, 25 mg daily, was at least as effective for hypertension as 50 and 75 mg with less perturbation of potassium. Use of smaller initial diuretic doses may provide equal efficacy with fewer side effects for many patients.

Original languageEnglish (US)
Pages (from-to)192-198
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume24
Issue number2
DOIs
StatePublished - Aug 1978

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Materson, B. J., Oster, J. R., Michael, U. F., Bolton, S. M., Burton, Z. C., Stambaugh, J. E., & Morledge, J. (1978). Dose response to chlorthalidone in patients with mild hypertension. Efficacy of a lower dose. Clinical Pharmacology and Therapeutics, 24(2), 192-198. https://doi.org/10.1002/cpt1978242192