Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24

K. Ranga Rama Krishnan, Merry Noel Miller, Michael J. Helms, Deborah Reed, James C. Ritchie, Charles Nemeroff, Bernard J. Carroll

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The authors examined the dose response relationship between plasma ACTH and cortisol concentrations after the administration of various doses of ACTH1-24 (0.025 μg, 0.125 μg, 0.25 μg, 1 μg, 250 μg) in dexamethasone-suppressed normal volunteers. A logarithmic dose-response relationship between the dose of ACTH administered and plasma cortisol concentration was found. Although there was considerable variability in plasma ACTH concentrations, there was, however, a definite correlation between area under the curve for ACTH and area under the curve for cortisol after the various doses of ACTH.

Original languageEnglish
Pages (from-to)240-243
Number of pages4
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume242
Issue number4
DOIs
StatePublished - Mar 1 1993
Externally publishedYes

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Adrenocorticotropic Hormone
Hydrocortisone
Area Under Curve
Dexamethasone
Healthy Volunteers

Keywords

  • ACTH cortisol and dose response
  • ACTH infusion

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24. / Krishnan, K. Ranga Rama; Miller, Merry Noel; Helms, Michael J.; Reed, Deborah; Ritchie, James C.; Nemeroff, Charles; Carroll, Bernard J.

In: European Archives of Psychiatry and Clinical Neuroscience, Vol. 242, No. 4, 01.03.1993, p. 240-243.

Research output: Contribution to journalArticle

Krishnan, K. Ranga Rama ; Miller, Merry Noel ; Helms, Michael J. ; Reed, Deborah ; Ritchie, James C. ; Nemeroff, Charles ; Carroll, Bernard J. / Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24. In: European Archives of Psychiatry and Clinical Neuroscience. 1993 ; Vol. 242, No. 4. pp. 240-243.
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