Dose-dependent electrophysiologic effects of amiodarone in the immature canine heart

Arthur S. Pickoff, Sharanjeet Singh, Celia J. Flinn, Edda Torres, Alan M. Ezrin, Henry Gelband

Research output: Contribution to journalArticle

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Abstract

The electrophysiologic effects of incremental doses of intravenous amiodarone were studied in the intact neonatal canine heart and were compared with the responses observed in the adult. Seven neonatal puppies aged 5 to 14 days, and 6 adult dogs were studied. Assessment of sinus and atrioventricular (AV) nodal function and atrial and ventricular refractory periods was performed using standard His bundle recording techniques and programmed extrastimulation before and after doses of 2.5, 5 and 10 mg/kg of intravenous amiodarone. Amiodarone depressed sinus node cycle length, sinus node recovery time and AV nodal conduction in both groups. Atrial and ventricular refractory periods were also prolonged in a dose-dependent fashion in both the neonatal and adult dogs. Although similar responses to amiodarone were observed in both groups, the immature dogs were more sensitive to amiodarone in prolongation of atrial refractory periods and depression of sinus node recovery time. The neonatal group, however, demonstrated more resistance to amiodarone-induced depression of AV nodal conduction. Thus, intravenous amiodarone produces dose-dependent electrophysiologic changes in the neonate similar to those in the adult, although the significant differences in drug sensitivity may be clinically important.

Original languageEnglish
Pages (from-to)621-625
Number of pages5
JournalThe American journal of cardiology
Volume52
Issue number5
DOIs
StatePublished - Sep 1 1983
Externally publishedYes

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Amiodarone
Canidae
Sinoatrial Node
Dogs
Atrial Function
Treatment-Resistant Depressive Disorder
Bundle of His
Ventricular Function
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pickoff, A. S., Singh, S., Flinn, C. J., Torres, E., Ezrin, A. M., & Gelband, H. (1983). Dose-dependent electrophysiologic effects of amiodarone in the immature canine heart. The American journal of cardiology, 52(5), 621-625. https://doi.org/10.1016/0002-9149(83)90038-3

Dose-dependent electrophysiologic effects of amiodarone in the immature canine heart. / Pickoff, Arthur S.; Singh, Sharanjeet; Flinn, Celia J.; Torres, Edda; Ezrin, Alan M.; Gelband, Henry.

In: The American journal of cardiology, Vol. 52, No. 5, 01.09.1983, p. 621-625.

Research output: Contribution to journalArticle

Pickoff, AS, Singh, S, Flinn, CJ, Torres, E, Ezrin, AM & Gelband, H 1983, 'Dose-dependent electrophysiologic effects of amiodarone in the immature canine heart', The American journal of cardiology, vol. 52, no. 5, pp. 621-625. https://doi.org/10.1016/0002-9149(83)90038-3
Pickoff, Arthur S. ; Singh, Sharanjeet ; Flinn, Celia J. ; Torres, Edda ; Ezrin, Alan M. ; Gelband, Henry. / Dose-dependent electrophysiologic effects of amiodarone in the immature canine heart. In: The American journal of cardiology. 1983 ; Vol. 52, No. 5. pp. 621-625.
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