Dorsal striatal size, shape, and metabolic rate in never-medicated and previously medicated schizophrenics performing a verbal learning task

Lina Shihabuddin, Monte S. Buchsbaum, Erin A. Hazlett, M. Mehmet Haznedar, Philip D. Harvey, Alan Newman, David B. Schnur, Jacqueline Spiegel-Cohen, Tsechung Wei, Josef Machac, Karin Knesaurek, Shankar Vallabhajosula, Melissa A. Biren, Tina M. Ciaravolo, Christina Luu-Hsia

Research output: Contribution to journalArticle

139 Scopus citations

Abstract

Background: Magnetic resonance imaging and positron emission tomography were used to study the size and metabolic rate of the caudate and the putamen in 18 patients with schizophrenia (n= 16) or schizo-affective disorder (n=2) and 24 age- and sex-matched control subjects. Methods: The patients were either never medicated (n = 7) or drug free (n= 11) for a median of 3 weeks. During uptake of fludeoxyglucose F 18, all patients performed a serial verbal learning test. Positron emission tomographic and magnetic resonance imaging scans were coregistered, and the caudate and the putamen were traced on the magnetic resonance image. Results: The striatum had a significantly lower relative metabolic rate in schizophrenics than in controls. Never-medicated patients had lower metabolic rates in the fight putamen (ventral part of the dorsal striatum) than previously medicated patients. The caudate was significantly smaller in never-medicated patients than in controls and largest in previously medicated patients. Patients with higher relative metabolic rates in the putamen scored higher on the Abnormal Involuntary Movements Scale. Conclusions: The findings are consistent with reports of striatal enlargement in previously medicated patients and size increases after neuroleptic treatment. Never-medicated patients, in contrast, had ventral striatal structures that were smaller and less active than those observed in controls and previously medicated patients.

Original languageEnglish (US)
Pages (from-to)235-243
Number of pages9
JournalArchives of General Psychiatry
Volume55
Issue number3
DOIs
StatePublished - Apr 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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    Shihabuddin, L., Buchsbaum, M. S., Hazlett, E. A., Haznedar, M. M., Harvey, P. D., Newman, A., Schnur, D. B., Spiegel-Cohen, J., Wei, T., Machac, J., Knesaurek, K., Vallabhajosula, S., Biren, M. A., Ciaravolo, T. M., & Luu-Hsia, C. (1998). Dorsal striatal size, shape, and metabolic rate in never-medicated and previously medicated schizophrenics performing a verbal learning task. Archives of General Psychiatry, 55(3), 235-243. https://doi.org/10.1001/archpsyc.55.3.235