Dorsal striatal size, shape, and metabolic rate in never-medicated and previously medicated schizophrenics performing a verbal learning task

L. Shihabuddin, M. S. Buchsbaum, E. A. Hazlett, M. M. Haznedar, Philip D Harvey, A. Newman, D. B. Schnur, J. Spiegel-Cohen, T. Wei, J. Machac, K. Knesaurek, S. Vallabhajosula, M. A. Biren, T. M. Ciaravolo, C. Luu-Hsia

Research output: Contribution to journalArticle

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Abstract

Background: Magnetic resonance imaging and positron emission tomography were used to study the size and metabolic rate of the caudate and the putamen in 18 patients with schizophrenia (n=16) or schizo-affective disorder (n=2) and 24 age- and sex-matched control subjects. Methods: The patients were either never medicated (n=) or drug free (n=11) for a median of 3 weeks. During uptake of fludeoxyglucose F 18, all patients performed a serial verbal learning test. Positron emission tomographic and magnetic resonance imaging scans were coregistered, and the caudate and the putamen were traced on the magnetic resonance image. Results: The striatum had a significantly lower relative metabolic rate in schizophrenics than in controls. Never- medicated patients had lower metabolic rates in the right putamen (ventral part of the dorsal striatum) than previously medicated patients. The caudate was significantly smaller in never-medicated patients than in controls and largest in previously medicated patients. Patients with higher relative metabolic rates in the putamen scored higher on the Abnormal Involuntary Movements Scale. Conclusions: The findings are consistent with reports of striatal enlargement in previously medicated patients and size increases after neuroleptic treatment. Never-medicated patients, in contrast, had ventral striatal structures that were smaller and less active than those observed in controls and previously medicated patients.

Original languageEnglish
Pages (from-to)235-243
Number of pages9
JournalArchives of Internal Medicine
Volume158
Issue number5
StatePublished - Mar 9 1998
Externally publishedYes

Fingerprint

Corpus Striatum
Verbal Learning
Putamen
Serial Learning
Magnetic Resonance Imaging
Fluorodeoxyglucose F18
Mood Disorders
Positron-Emission Tomography
Antipsychotic Agents
Schizophrenia
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Shihabuddin, L., Buchsbaum, M. S., Hazlett, E. A., Haznedar, M. M., Harvey, P. D., Newman, A., ... Luu-Hsia, C. (1998). Dorsal striatal size, shape, and metabolic rate in never-medicated and previously medicated schizophrenics performing a verbal learning task. Archives of Internal Medicine, 158(5), 235-243.

Dorsal striatal size, shape, and metabolic rate in never-medicated and previously medicated schizophrenics performing a verbal learning task. / Shihabuddin, L.; Buchsbaum, M. S.; Hazlett, E. A.; Haznedar, M. M.; Harvey, Philip D; Newman, A.; Schnur, D. B.; Spiegel-Cohen, J.; Wei, T.; Machac, J.; Knesaurek, K.; Vallabhajosula, S.; Biren, M. A.; Ciaravolo, T. M.; Luu-Hsia, C.

In: Archives of Internal Medicine, Vol. 158, No. 5, 09.03.1998, p. 235-243.

Research output: Contribution to journalArticle

Shihabuddin, L, Buchsbaum, MS, Hazlett, EA, Haznedar, MM, Harvey, PD, Newman, A, Schnur, DB, Spiegel-Cohen, J, Wei, T, Machac, J, Knesaurek, K, Vallabhajosula, S, Biren, MA, Ciaravolo, TM & Luu-Hsia, C 1998, 'Dorsal striatal size, shape, and metabolic rate in never-medicated and previously medicated schizophrenics performing a verbal learning task', Archives of Internal Medicine, vol. 158, no. 5, pp. 235-243.
Shihabuddin, L. ; Buchsbaum, M. S. ; Hazlett, E. A. ; Haznedar, M. M. ; Harvey, Philip D ; Newman, A. ; Schnur, D. B. ; Spiegel-Cohen, J. ; Wei, T. ; Machac, J. ; Knesaurek, K. ; Vallabhajosula, S. ; Biren, M. A. ; Ciaravolo, T. M. ; Luu-Hsia, C. / Dorsal striatal size, shape, and metabolic rate in never-medicated and previously medicated schizophrenics performing a verbal learning task. In: Archives of Internal Medicine. 1998 ; Vol. 158, No. 5. pp. 235-243.
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