Dopaminergic control of transmission from group II muscle afferents to spinal neurones in the cat and guinea-pig

B. Skoog, Brian R Noga

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effects of dopamine and its agonists on transmission from muscle afferents to spinal neurones were investigated in the cat and guinea-pig spinal cord, by measuring the drug effects on the amplitude of monosynaptic field potentials evoked by electrical stimulation of group I and group II muscle afferents. Local iontophoretic application of dopamine, the dopamine D1/D5 agonist SKF-38393 and the D2/D3/D4 agonist quinpirole all depressed the group II field potentials evoked at the base of the dorsal horn. Group II field potentials in the intermediate zone were depressed by dopamine to a similar degree as the dorsal horn field potentials, whereas the dopamine agonists were without effect upon them. The intermediate zone field potentials evoked by group I muscle afferents were not depressed by any of the drugs. The dopamine-evoked depression of the group II-evoked field potentials in the dorsal horn in the guinea-pig spinal cord was reduced by the simultaneous application of haloperidol. The results demonstrate that dopamine receptors mediate the depression of transmission from group II muscle afferents to interneurones in the dorsal horn, but not to neurones in the intermediate zone of the spinal cord.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalExperimental Brain Research
Volume105
Issue number1
DOIs
StatePublished - Jul 1 1995
Externally publishedYes

Fingerprint

Evoked Potentials
Dopamine
Guinea Pigs
Cats
Neurons
Muscles
Spinal Cord
Control Groups
Dopamine Agonists
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Quinpirole
Dopamine Receptors
Interneurons
Haloperidol
Pharmaceutical Preparations
Electric Stimulation
Spinal Cord Dorsal Horn

Keywords

  • Cat
  • Dopamine
  • Group II muscle afferents
  • Guinea-pig
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dopaminergic control of transmission from group II muscle afferents to spinal neurones in the cat and guinea-pig. / Skoog, B.; Noga, Brian R.

In: Experimental Brain Research, Vol. 105, No. 1, 01.07.1995, p. 39-47.

Research output: Contribution to journalArticle

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