The injection of a dopamine D2 receptor hammerhead ribozyme (20 μg) once daily for 5 days into the nucleus accumbens of rats resulted in an inhibition of stereotyped sniffing and locomotor activation produced by the selective dopamine D2 receptor agonist, quinpirole (0.4 mg kg-1 s.c.). The results suggest that ribozymes may be useful in the study of in vivo gene function in the brain. Copyright (C) 2000 Elsevier Science B.V.
- Dopamine D receptor
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience