Dopamine D2 receptor ribozyme inhibits quinpirole-induced stereotypy in rats

Peter Salmi, Brian S. Sproat, Janos Ludwig, Ruth Hale, Nicola Avery, Johanna Kela, Claes R Wahlestedt

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The injection of a dopamine D2 receptor hammerhead ribozyme (20 μg) once daily for 5 days into the nucleus accumbens of rats resulted in an inhibition of stereotyped sniffing and locomotor activation produced by the selective dopamine D2 receptor agonist, quinpirole (0.4 mg kg-1 s.c.). The results suggest that ribozymes may be useful in the study of in vivo gene function in the brain. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
JournalEuropean Journal of Pharmacology
Volume388
Issue number1
DOIs
StatePublished - Jan 24 2000
Externally publishedYes

Fingerprint

Quinpirole
Catalytic RNA
Dopamine D2 Receptors
Dopamine Agonists
Nucleus Accumbens
Injections
Brain
Genes
hammerhead ribozyme

Keywords

  • Dopamine D receptor
  • Ribozyme
  • Stereotypy

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Dopamine D2 receptor ribozyme inhibits quinpirole-induced stereotypy in rats. / Salmi, Peter; Sproat, Brian S.; Ludwig, Janos; Hale, Ruth; Avery, Nicola; Kela, Johanna; Wahlestedt, Claes R.

In: European Journal of Pharmacology, Vol. 388, No. 1, 24.01.2000.

Research output: Contribution to journalArticle

Salmi, Peter ; Sproat, Brian S. ; Ludwig, Janos ; Hale, Ruth ; Avery, Nicola ; Kela, Johanna ; Wahlestedt, Claes R. / Dopamine D2 receptor ribozyme inhibits quinpirole-induced stereotypy in rats. In: European Journal of Pharmacology. 2000 ; Vol. 388, No. 1.
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