Dopamine D2 receptor ribozyme inhibits quinpirole-induced stereotypy in rats

Peter Salmi, Brian S. Sproat, Janos Ludwig, Ruth Hale, Nicola Avery, Johanna Kela, Claes Wahlestedt

Research output: Contribution to journalArticle

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Abstract

The injection of a dopamine D2 receptor hammerhead ribozyme (20 μg) once daily for 5 days into the nucleus accumbens of rats resulted in an inhibition of stereotyped sniffing and locomotor activation produced by the selective dopamine D2 receptor agonist, quinpirole (0.4 mg kg-1 s.c.). The results suggest that ribozymes may be useful in the study of in vivo gene function in the brain. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)R1
JournalEuropean Journal of Pharmacology
Volume388
Issue number1
DOIs
StatePublished - Jan 24 2000
Externally publishedYes

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Keywords

  • Dopamine D receptor
  • Ribozyme
  • Stereotypy

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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