Donor/recipient enhancement of memory in rat hippocampus

Sam A. Deadwyler, Theodore W. Berger, Andrew J. Sweatt, Dong Song, Rosa H.M. Chan, Ioan Opris, Greg A. Gerhardt, Vasilis Z. Marmarelis, Robert E. Hampson

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The critical role of the mammalian hippocampus in the formation, translation and retrieval of memory has been documented over many decades. There are many theories of how the hippocampus operates to encode events and a precise mechanism was recently identified in rats performing a short-term memory task which demonstrated that successful information encoding was promoted via specific patterns of activity generated within ensembles of hippocampal neurons. In the study presented here, these "representations" were extracted via a customized non-linear multi-input multi-output (MIMO) mathematical model which allowed prediction of successful performance on specific trials within the testing session. A unique feature of this characterization was demonstrated when successful information encoding patterns were derived online from well-trained "donor" animals during difficult long-delay trials and delivered via online electrical stimulation to synchronously tested naïve "recipient" animals never before exposed to the delay feature of the task. By transferring such model-derived trained (donor) animal hippocampal firing patterns via stimulation to coupled naïve recipient animals, their task performance was facilitated in a direct "donor-recipient" manner. This provides the basis for utilizing extracted appropriate neural information from one brain to induce, recover, or enhance memory related processing in the brain of another subject.

Original languageEnglish (US)
Article number120
JournalFrontiers in Systems Neuroscience
Volume7
Issue numberDEC
DOIs
StatePublished - Dec 26 2013
Externally publishedYes

Fingerprint

Hippocampus
Brain
Task Performance and Analysis
Short-Term Memory
Electric Stimulation
Theoretical Models
Neurons

Keywords

  • Electrical stimulation
  • Ensemble
  • Memory-transfer
  • Non-linear model
  • Rodent

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Deadwyler, S. A., Berger, T. W., Sweatt, A. J., Song, D., Chan, R. H. M., Opris, I., ... Hampson, R. E. (2013). Donor/recipient enhancement of memory in rat hippocampus. Frontiers in Systems Neuroscience, 7(DEC), [120]. https://doi.org/10.3389/fnsys.2013.00120

Donor/recipient enhancement of memory in rat hippocampus. / Deadwyler, Sam A.; Berger, Theodore W.; Sweatt, Andrew J.; Song, Dong; Chan, Rosa H.M.; Opris, Ioan; Gerhardt, Greg A.; Marmarelis, Vasilis Z.; Hampson, Robert E.

In: Frontiers in Systems Neuroscience, Vol. 7, No. DEC, 120, 26.12.2013.

Research output: Contribution to journalArticle

Deadwyler, SA, Berger, TW, Sweatt, AJ, Song, D, Chan, RHM, Opris, I, Gerhardt, GA, Marmarelis, VZ & Hampson, RE 2013, 'Donor/recipient enhancement of memory in rat hippocampus', Frontiers in Systems Neuroscience, vol. 7, no. DEC, 120. https://doi.org/10.3389/fnsys.2013.00120
Deadwyler, Sam A. ; Berger, Theodore W. ; Sweatt, Andrew J. ; Song, Dong ; Chan, Rosa H.M. ; Opris, Ioan ; Gerhardt, Greg A. ; Marmarelis, Vasilis Z. ; Hampson, Robert E. / Donor/recipient enhancement of memory in rat hippocampus. In: Frontiers in Systems Neuroscience. 2013 ; Vol. 7, No. DEC.
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