Donor-derived fungal infections in organ transplant recipients: Guidelines of the American society of transplantation, infectious diseases community of practice

N. Singh, S. Huprikar, S. D. Burdette, Michele I Morris, J. E. Blair, L. J. Wheat

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Donor-derived fungal infections can be associated with serious complications in transplant recipients. Most cases of donor-derived candidiasis have occurred in kidney transplant recipients in whom contaminated preservation fluid is a commonly proposed source. Donors with cryptococcal disease, including those with unrecognized cryptococcal meningoencephalitis may transmit the infection with the allograft. Active histoplasmosis or undiagnosed and presumably asymptomatic infection in the donor that had not resolved by the time of death can result in donor-derived histoplasmosis in the recipient. Potential donors from an endemic area with either active or occult infection can also transmit coccidioidomycosis. Rare instances of aspergillosis and other mycoses, including agents of mucormycosis may also be transmitted from infected donors. Appropriate diagnostic evaluation and prompt initiation of appropriate antifungal therapy are warranted if donor-derived fungal infections are a consideration. This document discusses the characteristics, evaluation and approach to the management of donor-derived fungal infections in organ transplant recipients. This document presents the guidelines endorsed by the American Society of Transplantation regarding the characteristics, diagnostic evaluation and approach to the management of donor-derived fungal infections in organ transplant recipients.

Original languageEnglish
Pages (from-to)2414-2428
Number of pages15
JournalAmerican Journal of Transplantation
Volume12
Issue number9
DOIs
StatePublished - Sep 1 2012

Fingerprint

Mycoses
Communicable Diseases
Transplantation
Tissue Donors
Guidelines
Transplants
Histoplasmosis
Transplant Recipients
Coccidioidomycosis
Mucormycosis
Asymptomatic Infections
Meningoencephalitis
Aspergillosis
Candidiasis
Infection
Allografts
Kidney

Keywords

  • Candida
  • coccidioidomycosis
  • cryptococcosis
  • donor transmission
  • fungal infections
  • histoplasmosis
  • transplant

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

Cite this

Donor-derived fungal infections in organ transplant recipients : Guidelines of the American society of transplantation, infectious diseases community of practice. / Singh, N.; Huprikar, S.; Burdette, S. D.; Morris, Michele I; Blair, J. E.; Wheat, L. J.

In: American Journal of Transplantation, Vol. 12, No. 9, 01.09.2012, p. 2414-2428.

Research output: Contribution to journalArticle

@article{e9bbef5a24b8472797b2f2792a6b1275,
title = "Donor-derived fungal infections in organ transplant recipients: Guidelines of the American society of transplantation, infectious diseases community of practice",
abstract = "Donor-derived fungal infections can be associated with serious complications in transplant recipients. Most cases of donor-derived candidiasis have occurred in kidney transplant recipients in whom contaminated preservation fluid is a commonly proposed source. Donors with cryptococcal disease, including those with unrecognized cryptococcal meningoencephalitis may transmit the infection with the allograft. Active histoplasmosis or undiagnosed and presumably asymptomatic infection in the donor that had not resolved by the time of death can result in donor-derived histoplasmosis in the recipient. Potential donors from an endemic area with either active or occult infection can also transmit coccidioidomycosis. Rare instances of aspergillosis and other mycoses, including agents of mucormycosis may also be transmitted from infected donors. Appropriate diagnostic evaluation and prompt initiation of appropriate antifungal therapy are warranted if donor-derived fungal infections are a consideration. This document discusses the characteristics, evaluation and approach to the management of donor-derived fungal infections in organ transplant recipients. This document presents the guidelines endorsed by the American Society of Transplantation regarding the characteristics, diagnostic evaluation and approach to the management of donor-derived fungal infections in organ transplant recipients.",
keywords = "Candida, coccidioidomycosis, cryptococcosis, donor transmission, fungal infections, histoplasmosis, transplant",
author = "N. Singh and S. Huprikar and Burdette, {S. D.} and Morris, {Michele I} and Blair, {J. E.} and Wheat, {L. J.}",
year = "2012",
month = "9",
day = "1",
doi = "10.1111/j.1600-6143.2012.04100.x",
language = "English",
volume = "12",
pages = "2414--2428",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Donor-derived fungal infections in organ transplant recipients

T2 - Guidelines of the American society of transplantation, infectious diseases community of practice

AU - Singh, N.

AU - Huprikar, S.

AU - Burdette, S. D.

AU - Morris, Michele I

AU - Blair, J. E.

AU - Wheat, L. J.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Donor-derived fungal infections can be associated with serious complications in transplant recipients. Most cases of donor-derived candidiasis have occurred in kidney transplant recipients in whom contaminated preservation fluid is a commonly proposed source. Donors with cryptococcal disease, including those with unrecognized cryptococcal meningoencephalitis may transmit the infection with the allograft. Active histoplasmosis or undiagnosed and presumably asymptomatic infection in the donor that had not resolved by the time of death can result in donor-derived histoplasmosis in the recipient. Potential donors from an endemic area with either active or occult infection can also transmit coccidioidomycosis. Rare instances of aspergillosis and other mycoses, including agents of mucormycosis may also be transmitted from infected donors. Appropriate diagnostic evaluation and prompt initiation of appropriate antifungal therapy are warranted if donor-derived fungal infections are a consideration. This document discusses the characteristics, evaluation and approach to the management of donor-derived fungal infections in organ transplant recipients. This document presents the guidelines endorsed by the American Society of Transplantation regarding the characteristics, diagnostic evaluation and approach to the management of donor-derived fungal infections in organ transplant recipients.

AB - Donor-derived fungal infections can be associated with serious complications in transplant recipients. Most cases of donor-derived candidiasis have occurred in kidney transplant recipients in whom contaminated preservation fluid is a commonly proposed source. Donors with cryptococcal disease, including those with unrecognized cryptococcal meningoencephalitis may transmit the infection with the allograft. Active histoplasmosis or undiagnosed and presumably asymptomatic infection in the donor that had not resolved by the time of death can result in donor-derived histoplasmosis in the recipient. Potential donors from an endemic area with either active or occult infection can also transmit coccidioidomycosis. Rare instances of aspergillosis and other mycoses, including agents of mucormycosis may also be transmitted from infected donors. Appropriate diagnostic evaluation and prompt initiation of appropriate antifungal therapy are warranted if donor-derived fungal infections are a consideration. This document discusses the characteristics, evaluation and approach to the management of donor-derived fungal infections in organ transplant recipients. This document presents the guidelines endorsed by the American Society of Transplantation regarding the characteristics, diagnostic evaluation and approach to the management of donor-derived fungal infections in organ transplant recipients.

KW - Candida

KW - coccidioidomycosis

KW - cryptococcosis

KW - donor transmission

KW - fungal infections

KW - histoplasmosis

KW - transplant

UR - http://www.scopus.com/inward/record.url?scp=84865609793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865609793&partnerID=8YFLogxK

U2 - 10.1111/j.1600-6143.2012.04100.x

DO - 10.1111/j.1600-6143.2012.04100.x

M3 - Article

C2 - 22694672

AN - SCOPUS:84865609793

VL - 12

SP - 2414

EP - 2428

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 9

ER -