Abstract
One line of thought in organ transplantation feels that immunosuppressive drugs can lead to tolerance induction by allowing a previously unrecognized common mechanism of cell migration and microchimerism to occur, persist, and in some cases, become drug independent. It has been recognized that there is a spectrum of susceptibility of different organs to cellular rejection and that the variable ability of these organs to induce donor-specific nonreactivity reflects their comparative content of migratory leukocytes. Here, Thomas Starzl and colleagues discuss how many of the enigmas of transplantation immunology can be explained by this chimerism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 217-223 |
| Number of pages | 7 |
| Journal | Trends in Pharmacological Sciences |
| Volume | 14 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1993 |
ASJC Scopus subject areas
- Toxicology
- Pharmacology
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Starzl, T. E., Demetris, A. J., Murase, N., Thomson, A. W., Trucco, M., & Ricordi, C. (1993). Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation. Trends in Pharmacological Sciences, 14(5), 217-223. https://doi.org/10.1016/0165-6147(93)90212-3