Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation

Thomas E. Starzl; Anthony J. Demetris; Noriko Murase; Angus W. Thomson; Massimo Trucco; Camillo Ricordi

doi:10.1016/0165-6147(93)90212-3

Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation

Thomas E. Starzl, Anthony J. Demetris, Noriko Murase, Angus W. Thomson, Massimo Trucco, Camillo Ricordi

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

One line of thought in organ transplantation feels that immunosuppressive drugs can lead to tolerance induction by allowing a previously unrecognized common mechanism of cell migration and microchimerism to occur, persist, and in some cases, become drug independent. It has been recognized that there is a spectrum of susceptibility of different organs to cellular rejection and that the variable ability of these organs to induce donor-specific nonreactivity reflects their comparative content of migratory leukocytes. Here, Thomas Starzl and colleagues discuss how many of the enigmas of transplantation immunology can be explained by this chimerism.

Original language	English (US)
Pages (from-to)	217-223
Number of pages	7
Journal	Trends in Pharmacological Sciences
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/0165-6147(93)90212-3
State	Published - May 1993
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Pharmacology

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abstract = "One line of thought in organ transplantation feels that immunosuppressive drugs can lead to tolerance induction by allowing a previously unrecognized common mechanism of cell migration and microchimerism to occur, persist, and in some cases, become drug independent. It has been recognized that there is a spectrum of susceptibility of different organs to cellular rejection and that the variable ability of these organs to induce donor-specific nonreactivity reflects their comparative content of migratory leukocytes. Here, Thomas Starzl and colleagues discuss how many of the enigmas of transplantation immunology can be explained by this chimerism.",

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AU - Trucco, Massimo

AU - Ricordi, Camillo

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