TY - JOUR
T1 - Donor cell chimerism permitted by immunosuppressive drugs
T2 - a new view of organ transplantation
AU - Starzl, Thomas E.
AU - Demetris, Anthony J.
AU - Murase, Noriko
AU - Thomson, Angus W.
AU - Trucco, Massimo
AU - Ricordi, Camillo
PY - 1993/5
Y1 - 1993/5
N2 - One line of thought in organ transplantation feels that immunosuppressive drugs can lead to tolerance induction by allowing a previously unrecognized common mechanism of cell migration and microchimerism to occur, persist, and in some cases, become drug independent. It has been recognized that there is a spectrum of susceptibility of different organs to cellular rejection and that the variable ability of these organs to induce donor-specific nonreactivity reflects their comparative content of migratory leukocytes. Here, Thomas Starzl and colleagues discuss how many of the enigmas of transplantation immunology can be explained by this chimerism.
AB - One line of thought in organ transplantation feels that immunosuppressive drugs can lead to tolerance induction by allowing a previously unrecognized common mechanism of cell migration and microchimerism to occur, persist, and in some cases, become drug independent. It has been recognized that there is a spectrum of susceptibility of different organs to cellular rejection and that the variable ability of these organs to induce donor-specific nonreactivity reflects their comparative content of migratory leukocytes. Here, Thomas Starzl and colleagues discuss how many of the enigmas of transplantation immunology can be explained by this chimerism.
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U2 - 10.1016/0165-6147(93)90212-3
DO - 10.1016/0165-6147(93)90212-3
M3 - Article
C2 - 8212319
AN - SCOPUS:0027195580
VL - 14
SP - 217
EP - 223
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - 5
ER -