Donor bone marrow transplantation

Chimerism and tolerance

Spiros Delis, Gaetano Ciancio, George W Burke, Rolando Garcia-Morales, Joshua Miller

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Infusion of donor bone marrow (DBM)-derived cells continue to be tested in clinical protocols intended to induce specific immunologic tolerance. Central clonal deletion of donor-specific alloreactive cells associated with mixed chimerism reliably produced long-term graft tolerance. In this setting, depletion of recipient T cells by antilymphocyte antibodies and subsequent repopulation by donor hematopoietic cells after donor bone marrow infusion (DBMI) are prerequisites for tolerance induction. Major advances have been made in animal models and in pilot clinical trials and the key questions with the future perspectives are presented in this article.

Original languageEnglish
Pages (from-to)105-115
Number of pages11
JournalTransplant Immunology
Volume13
Issue number2
DOIs
StatePublished - Sep 1 2004

Fingerprint

Transplantation Tolerance
Chimerism
Bone Marrow Transplantation
Clonal Deletion
Antilymphocyte Serum
Clinical Protocols
Bone Marrow Cells
Animal Models
Bone Marrow
Clinical Trials
T-Lymphocytes

Keywords

  • Bone marrow transplant
  • Chimerism
  • Tolerance

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Transplantation

Cite this

Donor bone marrow transplantation : Chimerism and tolerance. / Delis, Spiros; Ciancio, Gaetano; Burke, George W; Garcia-Morales, Rolando; Miller, Joshua.

In: Transplant Immunology, Vol. 13, No. 2, 01.09.2004, p. 105-115.

Research output: Contribution to journalArticle

Delis, Spiros ; Ciancio, Gaetano ; Burke, George W ; Garcia-Morales, Rolando ; Miller, Joshua. / Donor bone marrow transplantation : Chimerism and tolerance. In: Transplant Immunology. 2004 ; Vol. 13, No. 2. pp. 105-115.
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