Dominant myocardial disease diagnosed by fetal presentation of proband with an aneurysm of the muscular interventricular septum

M. T. Donofrio, D. R. Allen, M. Tekin, J. Bodurtha

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We describe an inherited form of a disorder in which four patients spanning three generations were affected with congenital myocardial disease. The youngest member of the family, diagnosed as a fetus with a large aneurysm of the muscular interventricular septum, demonstrates an antenatal pathogenic process. Study of the specific findings in each patient suggests that congenital aneurysms of the muscular interventricular septum may be in some way associated with specific developmental pathways of the heart. We believe that screening family members of patients with muscular interventricular septal aneurysms may be indicated to assess for silent myocardial disease.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalPediatric Cardiology
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Keywords

  • Apoptosis
  • Genetic cardiomyopathy
  • Interventricular septal aneurysm

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

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