Does the menstrual cycle influence the sensitivity of vagally mediated baroreflexes?

William H. Cooke, David Ludwig, Paul S. Hogg, Dwain L. Eckberg, Victor A. Convertino

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The menstrual cycle provokes several physiological changes that could influence autonomic regulatory mechanisms. We studied the carotid-cardiac baroreflex in ten healthy young women on four occasions over the course of their menstrual cycles (days 0-8, 9-14, 15-20 and 21-25). We drew blood during each session for analysis of oestrogen, progesterone and noradrenaline (norepinephrine) levels, and assessed carotid-cardiac baroreflex function by analysing R-R interval responses to graded neck pressure sequences. Oestrogen levels followed a classical two-peak (cubic) response, with elevated levels on days 9-14 and 21-25 compared with days 0-8 and 15-20 (P = 0.0032), while progesterone levels increased exponentially from days 9-14 to days 21-25 (P = 0.0063). Noradrenaline levels increased from an average of 137 pg/ml during the first three measurement periods to 199 pg/ml during days 21-25 (P = 0.0456). Carotid-cardiac baroreflex gain and operational point were not statistically different at any of the time points during the menstrual cycle (P ≥ 0.18). These findings are consistent with the notion that beat-to-beat vagal-cardiac regulation does not change over the course of the normal menstrual cycle.

Original languageEnglish
Pages (from-to)639-644
Number of pages6
JournalClinical Science
Volume102
Issue number6
DOIs
StatePublished - Jun 22 2002
Externally publishedYes

Fingerprint

Baroreflex
Menstrual Cycle
Norepinephrine
Progesterone
Estrogens
Neck
Pressure

Keywords

  • Baroreflex
  • Reproductive hormones
  • Women

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cooke, W. H., Ludwig, D., Hogg, P. S., Eckberg, D. L., & Convertino, V. A. (2002). Does the menstrual cycle influence the sensitivity of vagally mediated baroreflexes? Clinical Science, 102(6), 639-644. https://doi.org/10.1042/CS20010326

Does the menstrual cycle influence the sensitivity of vagally mediated baroreflexes? / Cooke, William H.; Ludwig, David; Hogg, Paul S.; Eckberg, Dwain L.; Convertino, Victor A.

In: Clinical Science, Vol. 102, No. 6, 22.06.2002, p. 639-644.

Research output: Contribution to journalArticle

Cooke, WH, Ludwig, D, Hogg, PS, Eckberg, DL & Convertino, VA 2002, 'Does the menstrual cycle influence the sensitivity of vagally mediated baroreflexes?', Clinical Science, vol. 102, no. 6, pp. 639-644. https://doi.org/10.1042/CS20010326
Cooke, William H. ; Ludwig, David ; Hogg, Paul S. ; Eckberg, Dwain L. ; Convertino, Victor A. / Does the menstrual cycle influence the sensitivity of vagally mediated baroreflexes?. In: Clinical Science. 2002 ; Vol. 102, No. 6. pp. 639-644.
@article{94b4f03ef8de46a08d9bfa6a62cb494f,
title = "Does the menstrual cycle influence the sensitivity of vagally mediated baroreflexes?",
abstract = "The menstrual cycle provokes several physiological changes that could influence autonomic regulatory mechanisms. We studied the carotid-cardiac baroreflex in ten healthy young women on four occasions over the course of their menstrual cycles (days 0-8, 9-14, 15-20 and 21-25). We drew blood during each session for analysis of oestrogen, progesterone and noradrenaline (norepinephrine) levels, and assessed carotid-cardiac baroreflex function by analysing R-R interval responses to graded neck pressure sequences. Oestrogen levels followed a classical two-peak (cubic) response, with elevated levels on days 9-14 and 21-25 compared with days 0-8 and 15-20 (P = 0.0032), while progesterone levels increased exponentially from days 9-14 to days 21-25 (P = 0.0063). Noradrenaline levels increased from an average of 137 pg/ml during the first three measurement periods to 199 pg/ml during days 21-25 (P = 0.0456). Carotid-cardiac baroreflex gain and operational point were not statistically different at any of the time points during the menstrual cycle (P ≥ 0.18). These findings are consistent with the notion that beat-to-beat vagal-cardiac regulation does not change over the course of the normal menstrual cycle.",
keywords = "Baroreflex, Reproductive hormones, Women",
author = "Cooke, {William H.} and David Ludwig and Hogg, {Paul S.} and Eckberg, {Dwain L.} and Convertino, {Victor A.}",
year = "2002",
month = "6",
day = "22",
doi = "10.1042/CS20010326",
language = "English",
volume = "102",
pages = "639--644",
journal = "Clinical Science",
issn = "0143-5221",
publisher = "Portland Press Ltd.",
number = "6",

}

TY - JOUR

T1 - Does the menstrual cycle influence the sensitivity of vagally mediated baroreflexes?

AU - Cooke, William H.

AU - Ludwig, David

AU - Hogg, Paul S.

AU - Eckberg, Dwain L.

AU - Convertino, Victor A.

PY - 2002/6/22

Y1 - 2002/6/22

N2 - The menstrual cycle provokes several physiological changes that could influence autonomic regulatory mechanisms. We studied the carotid-cardiac baroreflex in ten healthy young women on four occasions over the course of their menstrual cycles (days 0-8, 9-14, 15-20 and 21-25). We drew blood during each session for analysis of oestrogen, progesterone and noradrenaline (norepinephrine) levels, and assessed carotid-cardiac baroreflex function by analysing R-R interval responses to graded neck pressure sequences. Oestrogen levels followed a classical two-peak (cubic) response, with elevated levels on days 9-14 and 21-25 compared with days 0-8 and 15-20 (P = 0.0032), while progesterone levels increased exponentially from days 9-14 to days 21-25 (P = 0.0063). Noradrenaline levels increased from an average of 137 pg/ml during the first three measurement periods to 199 pg/ml during days 21-25 (P = 0.0456). Carotid-cardiac baroreflex gain and operational point were not statistically different at any of the time points during the menstrual cycle (P ≥ 0.18). These findings are consistent with the notion that beat-to-beat vagal-cardiac regulation does not change over the course of the normal menstrual cycle.

AB - The menstrual cycle provokes several physiological changes that could influence autonomic regulatory mechanisms. We studied the carotid-cardiac baroreflex in ten healthy young women on four occasions over the course of their menstrual cycles (days 0-8, 9-14, 15-20 and 21-25). We drew blood during each session for analysis of oestrogen, progesterone and noradrenaline (norepinephrine) levels, and assessed carotid-cardiac baroreflex function by analysing R-R interval responses to graded neck pressure sequences. Oestrogen levels followed a classical two-peak (cubic) response, with elevated levels on days 9-14 and 21-25 compared with days 0-8 and 15-20 (P = 0.0032), while progesterone levels increased exponentially from days 9-14 to days 21-25 (P = 0.0063). Noradrenaline levels increased from an average of 137 pg/ml during the first three measurement periods to 199 pg/ml during days 21-25 (P = 0.0456). Carotid-cardiac baroreflex gain and operational point were not statistically different at any of the time points during the menstrual cycle (P ≥ 0.18). These findings are consistent with the notion that beat-to-beat vagal-cardiac regulation does not change over the course of the normal menstrual cycle.

KW - Baroreflex

KW - Reproductive hormones

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=0036273560&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036273560&partnerID=8YFLogxK

U2 - 10.1042/CS20010326

DO - 10.1042/CS20010326

M3 - Article

C2 - 12049617

AN - SCOPUS:0036273560

VL - 102

SP - 639

EP - 644

JO - Clinical Science

JF - Clinical Science

SN - 0143-5221

IS - 6

ER -