Does the menstrual cycle influence the sensitivity of vagally mediated baroreflexes?

William H. Cooke, David A. Ludwig, Paul S. Hogg, Dwain L. Eckberg, Victor A. Convertino

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The menstrual cycle provokes several physiological changes that could influence autonomic regulatory mechanisms. We studied the carotid-cardiac baroreflex in ten healthy young women on four occasions over the course of their menstrual cycles (days 0-8, 9-14, 15-20 and 21-25). We drew blood during each session for analysis of oestrogen, progesterone and noradrenaline (norepinephrine) levels, and assessed carotid-cardiac baroreflex function by analysing R-R interval responses to graded neck pressure sequences. Oestrogen levels followed a classical two-peak (cubic) response, with elevated levels on days 9-14 and 21-25 compared with days 0-8 and 15-20 (P = 0.0032), while progesterone levels increased exponentially from days 9-14 to days 21-25 (P = 0.0063). Noradrenaline levels increased from an average of 137 pg/ml during the first three measurement periods to 199 pg/ml during days 21-25 (P = 0.0456). Carotid-cardiac baroreflex gain and operational point were not statistically different at any of the time points during the menstrual cycle (P ≥ 0.18). These findings are consistent with the notion that beat-to-beat vagal-cardiac regulation does not change over the course of the normal menstrual cycle.

Original languageEnglish (US)
Pages (from-to)639-644
Number of pages6
JournalClinical science
Volume102
Issue number6
DOIs
StatePublished - Jun 22 2002

Keywords

  • Baroreflex
  • Reproductive hormones
  • Women

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Does the menstrual cycle influence the sensitivity of vagally mediated baroreflexes?'. Together they form a unique fingerprint.

  • Cite this

    Cooke, W. H., Ludwig, D. A., Hogg, P. S., Eckberg, D. L., & Convertino, V. A. (2002). Does the menstrual cycle influence the sensitivity of vagally mediated baroreflexes? Clinical science, 102(6), 639-644. https://doi.org/10.1042/CS20010326