Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?

Robert A. Grossman, Felipe E. Pedroso, Margaret M Byrne, Leonidas G. Koniaris, Subhasis Misra

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background and Objectives: Extrapulmonary small cell carcinomas (EPSCC) are rare tumors where therapy remains poorly defined. We sought to determine the impact of surgical extirpation and radiation therapy for outcomes of EPSCC. Methods: The Surveillance, Epidemiology, and End Results: (SEER) database was queried for patients with EPSCC which were further categorized by site and evaluated for survival by specific treatment strategy. Results: We identified 94,173 patients with small cell carcinoma of which 88,605 (94.1%) and 5,568 (5.9%) had pulmonary small cell carcinoma and EPSCC, respectively. EPSCC patients were subdivided by site with the following proportions: genitourinary (24.1%), gastrointestinal (22.1%), head and neck (7.1%), breast (4%), and miscellaneous (42.7%). Overall EPSSC and specifically gastrointestinal disease had significantly improved median, 5- and 10-year survival with surgery and/or radiation for all stages and sizes. For all EPSCCs multivariate analysis revealed age (>50), gender (female), stage (regional, distant), radiation, and surgery to be independent predictors of survival. Conclusions: Although outcomes for EPSCC remains poor, both surgery and radiation is shown to significantly improve median, 5- and 10-year survival rates. EPSCC patients who are potential candidates for surgical resection or radiation therapy may benefit from these treatments.

Original languageEnglish
Pages (from-to)604-612
Number of pages9
JournalJournal of Surgical Oncology
Volume104
Issue number6
DOIs
StatePublished - Nov 1 2011

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Small Cell Carcinoma
Radiotherapy
Survival
Neoplasms
Radiation
Gastrointestinal Diseases
Epidemiology
Breast
Neck
Therapeutics
Multivariate Analysis
Survival Rate
Head
Databases
Lung

Keywords

  • oncology
  • outcomes
  • SEER
  • treatment

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers? / Grossman, Robert A.; Pedroso, Felipe E.; Byrne, Margaret M; Koniaris, Leonidas G.; Misra, Subhasis.

In: Journal of Surgical Oncology, Vol. 104, No. 6, 01.11.2011, p. 604-612.

Research output: Contribution to journalArticle

Grossman, Robert A. ; Pedroso, Felipe E. ; Byrne, Margaret M ; Koniaris, Leonidas G. ; Misra, Subhasis. / Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?. In: Journal of Surgical Oncology. 2011 ; Vol. 104, No. 6. pp. 604-612.
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