Abstract
Background and Objectives: Extrapulmonary small cell carcinomas (EPSCC) are rare tumors where therapy remains poorly defined. We sought to determine the impact of surgical extirpation and radiation therapy for outcomes of EPSCC. Methods: The Surveillance, Epidemiology, and End Results: (SEER) database was queried for patients with EPSCC which were further categorized by site and evaluated for survival by specific treatment strategy. Results: We identified 94,173 patients with small cell carcinoma of which 88,605 (94.1%) and 5,568 (5.9%) had pulmonary small cell carcinoma and EPSCC, respectively. EPSCC patients were subdivided by site with the following proportions: genitourinary (24.1%), gastrointestinal (22.1%), head and neck (7.1%), breast (4%), and miscellaneous (42.7%). Overall EPSSC and specifically gastrointestinal disease had significantly improved median, 5- and 10-year survival with surgery and/or radiation for all stages and sizes. For all EPSCCs multivariate analysis revealed age (>50), gender (female), stage (regional, distant), radiation, and surgery to be independent predictors of survival. Conclusions: Although outcomes for EPSCC remains poor, both surgery and radiation is shown to significantly improve median, 5- and 10-year survival rates. EPSCC patients who are potential candidates for surgical resection or radiation therapy may benefit from these treatments.
| Original language | English |
|---|---|
| Pages (from-to) | 604-612 |
| Number of pages | 9 |
| Journal | Journal of Surgical Oncology |
| Volume | 104 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1 2011 |
Fingerprint
Keywords
- oncology
- outcomes
- SEER
- treatment
ASJC Scopus subject areas
- Surgery
- Oncology
Cite this
Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers? / Grossman, Robert A.; Pedroso, Felipe E.; Byrne, Margaret M; Koniaris, Leonidas G.; Misra, Subhasis.
In: Journal of Surgical Oncology, Vol. 104, No. 6, 01.11.2011, p. 604-612.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?
AU - Grossman, Robert A.
AU - Pedroso, Felipe E.
AU - Byrne, Margaret M
AU - Koniaris, Leonidas G.
AU - Misra, Subhasis
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Background and Objectives: Extrapulmonary small cell carcinomas (EPSCC) are rare tumors where therapy remains poorly defined. We sought to determine the impact of surgical extirpation and radiation therapy for outcomes of EPSCC. Methods: The Surveillance, Epidemiology, and End Results: (SEER) database was queried for patients with EPSCC which were further categorized by site and evaluated for survival by specific treatment strategy. Results: We identified 94,173 patients with small cell carcinoma of which 88,605 (94.1%) and 5,568 (5.9%) had pulmonary small cell carcinoma and EPSCC, respectively. EPSCC patients were subdivided by site with the following proportions: genitourinary (24.1%), gastrointestinal (22.1%), head and neck (7.1%), breast (4%), and miscellaneous (42.7%). Overall EPSSC and specifically gastrointestinal disease had significantly improved median, 5- and 10-year survival with surgery and/or radiation for all stages and sizes. For all EPSCCs multivariate analysis revealed age (>50), gender (female), stage (regional, distant), radiation, and surgery to be independent predictors of survival. Conclusions: Although outcomes for EPSCC remains poor, both surgery and radiation is shown to significantly improve median, 5- and 10-year survival rates. EPSCC patients who are potential candidates for surgical resection or radiation therapy may benefit from these treatments.
AB - Background and Objectives: Extrapulmonary small cell carcinomas (EPSCC) are rare tumors where therapy remains poorly defined. We sought to determine the impact of surgical extirpation and radiation therapy for outcomes of EPSCC. Methods: The Surveillance, Epidemiology, and End Results: (SEER) database was queried for patients with EPSCC which were further categorized by site and evaluated for survival by specific treatment strategy. Results: We identified 94,173 patients with small cell carcinoma of which 88,605 (94.1%) and 5,568 (5.9%) had pulmonary small cell carcinoma and EPSCC, respectively. EPSCC patients were subdivided by site with the following proportions: genitourinary (24.1%), gastrointestinal (22.1%), head and neck (7.1%), breast (4%), and miscellaneous (42.7%). Overall EPSSC and specifically gastrointestinal disease had significantly improved median, 5- and 10-year survival with surgery and/or radiation for all stages and sizes. For all EPSCCs multivariate analysis revealed age (>50), gender (female), stage (regional, distant), radiation, and surgery to be independent predictors of survival. Conclusions: Although outcomes for EPSCC remains poor, both surgery and radiation is shown to significantly improve median, 5- and 10-year survival rates. EPSCC patients who are potential candidates for surgical resection or radiation therapy may benefit from these treatments.
KW - oncology
KW - outcomes
KW - SEER
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=80955178833&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80955178833&partnerID=8YFLogxK
U2 - 10.1002/jso.21976
DO - 10.1002/jso.21976
M3 - Article
VL - 104
SP - 604
EP - 612
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 6
ER -