Does erythropoietin modulate human hair follicle melanocyte activities in situ?

Eniko Bodó, Friederike Wiersma, Wolfgang Funk, Arno Kromminga, Wolfgang Jelkmann, Ralf Paus

Research output: Contribution to journalLetter

1 Citation (Scopus)

Abstract

Erythropoietin (EPO) is now appreciated for not only drive erythopoiesis, but also to exert additional functions. Since we had previously shown that human hair follicles (HFs) are both an extra-renal source and an extra-medullary target of EPO, we have now studied whether one such function is the regulation of HF pigmentation. Human anagen VI HFs were treated with EPO (100 IU/ml) in serum-free organ culture. Unexpectedly, we noticed greatly divergent pigmentary effects of EPO, since both up- and down-regulation of HF melanin content and tyrosinase activity in situ was seen in HF derived from different individuals. These divergent effects could not be attributed to differences in skin regions, the total HF melanocyte number or specific traits of individual HF donors. Our pilot study provides first evidence suggesting that EPO may modulate normal human melanocyte functions under physiologically relevant conditions in situ.

Original languageEnglish (US)
Pages (from-to)65-67
Number of pages3
JournalExperimental Dermatology
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Hair Follicle
Melanocytes
Erythropoietin
Monophenol Monooxygenase
Melanins
Skin
Organ Culture Techniques
Pigmentation
Up-Regulation
Down-Regulation
Kidney
Serum

Keywords

  • Erythropoietin
  • Hair follicle
  • Melanocytes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Does erythropoietin modulate human hair follicle melanocyte activities in situ? / Bodó, Eniko; Wiersma, Friederike; Funk, Wolfgang; Kromminga, Arno; Jelkmann, Wolfgang; Paus, Ralf.

In: Experimental Dermatology, Vol. 19, No. 1, 01.01.2010, p. 65-67.

Research output: Contribution to journalLetter

Bodó, Eniko ; Wiersma, Friederike ; Funk, Wolfgang ; Kromminga, Arno ; Jelkmann, Wolfgang ; Paus, Ralf. / Does erythropoietin modulate human hair follicle melanocyte activities in situ?. In: Experimental Dermatology. 2010 ; Vol. 19, No. 1. pp. 65-67.
@article{4bf511aa73f844b9b46ebf97209297ae,
title = "Does erythropoietin modulate human hair follicle melanocyte activities in situ?",
abstract = "Erythropoietin (EPO) is now appreciated for not only drive erythopoiesis, but also to exert additional functions. Since we had previously shown that human hair follicles (HFs) are both an extra-renal source and an extra-medullary target of EPO, we have now studied whether one such function is the regulation of HF pigmentation. Human anagen VI HFs were treated with EPO (100 IU/ml) in serum-free organ culture. Unexpectedly, we noticed greatly divergent pigmentary effects of EPO, since both up- and down-regulation of HF melanin content and tyrosinase activity in situ was seen in HF derived from different individuals. These divergent effects could not be attributed to differences in skin regions, the total HF melanocyte number or specific traits of individual HF donors. Our pilot study provides first evidence suggesting that EPO may modulate normal human melanocyte functions under physiologically relevant conditions in situ.",
keywords = "Erythropoietin, Hair follicle, Melanocytes",
author = "Eniko Bod{\'o} and Friederike Wiersma and Wolfgang Funk and Arno Kromminga and Wolfgang Jelkmann and Ralf Paus",
year = "2010",
month = "1",
day = "1",
doi = "10.1111/j.1600-0625.2009.00938.x",
language = "English (US)",
volume = "19",
pages = "65--67",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Does erythropoietin modulate human hair follicle melanocyte activities in situ?

AU - Bodó, Eniko

AU - Wiersma, Friederike

AU - Funk, Wolfgang

AU - Kromminga, Arno

AU - Jelkmann, Wolfgang

AU - Paus, Ralf

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Erythropoietin (EPO) is now appreciated for not only drive erythopoiesis, but also to exert additional functions. Since we had previously shown that human hair follicles (HFs) are both an extra-renal source and an extra-medullary target of EPO, we have now studied whether one such function is the regulation of HF pigmentation. Human anagen VI HFs were treated with EPO (100 IU/ml) in serum-free organ culture. Unexpectedly, we noticed greatly divergent pigmentary effects of EPO, since both up- and down-regulation of HF melanin content and tyrosinase activity in situ was seen in HF derived from different individuals. These divergent effects could not be attributed to differences in skin regions, the total HF melanocyte number or specific traits of individual HF donors. Our pilot study provides first evidence suggesting that EPO may modulate normal human melanocyte functions under physiologically relevant conditions in situ.

AB - Erythropoietin (EPO) is now appreciated for not only drive erythopoiesis, but also to exert additional functions. Since we had previously shown that human hair follicles (HFs) are both an extra-renal source and an extra-medullary target of EPO, we have now studied whether one such function is the regulation of HF pigmentation. Human anagen VI HFs were treated with EPO (100 IU/ml) in serum-free organ culture. Unexpectedly, we noticed greatly divergent pigmentary effects of EPO, since both up- and down-regulation of HF melanin content and tyrosinase activity in situ was seen in HF derived from different individuals. These divergent effects could not be attributed to differences in skin regions, the total HF melanocyte number or specific traits of individual HF donors. Our pilot study provides first evidence suggesting that EPO may modulate normal human melanocyte functions under physiologically relevant conditions in situ.

KW - Erythropoietin

KW - Hair follicle

KW - Melanocytes

UR - http://www.scopus.com/inward/record.url?scp=72549112268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72549112268&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0625.2009.00938.x

DO - 10.1111/j.1600-0625.2009.00938.x

M3 - Letter

C2 - 19645852

AN - SCOPUS:72549112268

VL - 19

SP - 65

EP - 67

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 0906-6705

IS - 1

ER -