Does dysregulation of catechol-o-methyltransferase predispose to opioid-induced hallucinations? A report of a patient with microdeletion of chromosome 22 and opioid-associated hallucinations

Melvin C. Gitlin, Bradley K. Taylor, Philip L. Kalarickal, Eric D. Lonseth

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Velocardiofacial syndrome is a genetic disorder associated with a microdeletion on the long arm of chromosome 22, and this segment is responsible for coding catechol-O-methyltransferase, an enzyme involved in dopamine degradation. We submit a case of velocardiofacial syndrome and Madelung deformity of the wrists presenting with hallucinatory phenomena associated with opioid exposure. Overactivity of the dopaminergic system has been postulated to cause schizophrenia in this population, and here we speculate that dysregulation of dopamine metabolism may have predisposed our patient to an increased risk of opioid-induced hallucinations. Further research is necessary to explore this relationship.

Original languageEnglish
Pages (from-to)84-86
Number of pages3
JournalPain Medicine
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Fingerprint

DiGeorge Syndrome
Catechol O-Methyltransferase
Chromosomes, Human, Pair 22
Hallucinations
Opioid Analgesics
Dopamine
Inborn Genetic Diseases
Wrist
Schizophrenia
Enzymes
Research
Population
Madelung Deformity

Keywords

  • Catechol-O-Methyltransferase
  • Genetic Variation
  • Hallucinations
  • Opioid
  • Pain
  • Velocardiofacial Syndrome

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Does dysregulation of catechol-o-methyltransferase predispose to opioid-induced hallucinations? A report of a patient with microdeletion of chromosome 22 and opioid-associated hallucinations. / Gitlin, Melvin C.; Taylor, Bradley K.; Kalarickal, Philip L.; Lonseth, Eric D.

In: Pain Medicine, Vol. 8, No. 1, 01.01.2007, p. 84-86.

Research output: Contribution to journalArticle

@article{ec287ab1068f4fa1a94a7d4279b03424,
title = "Does dysregulation of catechol-o-methyltransferase predispose to opioid-induced hallucinations? A report of a patient with microdeletion of chromosome 22 and opioid-associated hallucinations",
abstract = "Velocardiofacial syndrome is a genetic disorder associated with a microdeletion on the long arm of chromosome 22, and this segment is responsible for coding catechol-O-methyltransferase, an enzyme involved in dopamine degradation. We submit a case of velocardiofacial syndrome and Madelung deformity of the wrists presenting with hallucinatory phenomena associated with opioid exposure. Overactivity of the dopaminergic system has been postulated to cause schizophrenia in this population, and here we speculate that dysregulation of dopamine metabolism may have predisposed our patient to an increased risk of opioid-induced hallucinations. Further research is necessary to explore this relationship.",
keywords = "Catechol-O-Methyltransferase, Genetic Variation, Hallucinations, Opioid, Pain, Velocardiofacial Syndrome",
author = "Gitlin, {Melvin C.} and Taylor, {Bradley K.} and Kalarickal, {Philip L.} and Lonseth, {Eric D.}",
year = "2007",
month = "1",
day = "1",
doi = "10.1111/j.1526-4637.2007.00141.x",
language = "English",
volume = "8",
pages = "84--86",
journal = "Pain Medicine",
issn = "1526-2375",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Does dysregulation of catechol-o-methyltransferase predispose to opioid-induced hallucinations? A report of a patient with microdeletion of chromosome 22 and opioid-associated hallucinations

AU - Gitlin, Melvin C.

AU - Taylor, Bradley K.

AU - Kalarickal, Philip L.

AU - Lonseth, Eric D.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Velocardiofacial syndrome is a genetic disorder associated with a microdeletion on the long arm of chromosome 22, and this segment is responsible for coding catechol-O-methyltransferase, an enzyme involved in dopamine degradation. We submit a case of velocardiofacial syndrome and Madelung deformity of the wrists presenting with hallucinatory phenomena associated with opioid exposure. Overactivity of the dopaminergic system has been postulated to cause schizophrenia in this population, and here we speculate that dysregulation of dopamine metabolism may have predisposed our patient to an increased risk of opioid-induced hallucinations. Further research is necessary to explore this relationship.

AB - Velocardiofacial syndrome is a genetic disorder associated with a microdeletion on the long arm of chromosome 22, and this segment is responsible for coding catechol-O-methyltransferase, an enzyme involved in dopamine degradation. We submit a case of velocardiofacial syndrome and Madelung deformity of the wrists presenting with hallucinatory phenomena associated with opioid exposure. Overactivity of the dopaminergic system has been postulated to cause schizophrenia in this population, and here we speculate that dysregulation of dopamine metabolism may have predisposed our patient to an increased risk of opioid-induced hallucinations. Further research is necessary to explore this relationship.

KW - Catechol-O-Methyltransferase

KW - Genetic Variation

KW - Hallucinations

KW - Opioid

KW - Pain

KW - Velocardiofacial Syndrome

UR - http://www.scopus.com/inward/record.url?scp=33846354587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846354587&partnerID=8YFLogxK

U2 - 10.1111/j.1526-4637.2007.00141.x

DO - 10.1111/j.1526-4637.2007.00141.x

M3 - Article

C2 - 17244108

AN - SCOPUS:33846354587

VL - 8

SP - 84

EP - 86

JO - Pain Medicine

JF - Pain Medicine

SN - 1526-2375

IS - 1

ER -