Does dysregulation of catechol-o-methyltransferase predispose to opioid-induced hallucinations? A report of a patient with microdeletion of chromosome 22 and opioid-associated hallucinations

Melvin C. Gitlin, Bradley K. Taylor, Philip L. Kalarickal, Eric D. Lonseth

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Velocardiofacial syndrome is a genetic disorder associated with a microdeletion on the long arm of chromosome 22, and this segment is responsible for coding catechol-O-methyltransferase, an enzyme involved in dopamine degradation. We submit a case of velocardiofacial syndrome and Madelung deformity of the wrists presenting with hallucinatory phenomena associated with opioid exposure. Overactivity of the dopaminergic system has been postulated to cause schizophrenia in this population, and here we speculate that dysregulation of dopamine metabolism may have predisposed our patient to an increased risk of opioid-induced hallucinations. Further research is necessary to explore this relationship.

Original languageEnglish (US)
Pages (from-to)84-86
Number of pages3
JournalPain Medicine
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2007

Keywords

  • Catechol-O-Methyltransferase
  • Genetic Variation
  • Hallucinations
  • Opioid
  • Pain
  • Velocardiofacial Syndrome

ASJC Scopus subject areas

  • Clinical Neurology

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