Does being female provide a neuroprotective advantage following spinal cord injury?

Jeffrey P. Datto, Jackie Yang, W. Dalton Dietrich, Damien D Pearse

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

It has been controversial whether gender has any effect on recovery following spinal cord injury (SCI). Past experimental and clinical research aimed at addressing this subject has led to constrasting findings on whether females hold any advantage in locomotor recovery. Additionally, for studies supporting the notion of a female gender related advantage, a definite cause has not been explained. In a recent study, using large sample sizes for comparative male and female spinal cord injury cohorts, we reported that a significant gender advantage favoring females existed in both tissue preservation and functional recovery after taking into consideration discrepancies in age and weight of the animals across sexes. Prior animal research frequently used sample sizes that were too small to determine significance with certainty and also did not account for two other factors that influence locomotor performance: age and weight. Our finding is important in light of controversy surrounding the effect of gender on outcome and the fact that SCI affects more than ten thousand new individuals annually, a population that is disproportionately male. By deepening our understanding of why a gender advantage exists, potential new therapeutics can be designed to improve recovery for the male population following the initial trauma or putatively augment the neuroprotective privilege in females for enhanced outcomes.

Original languageEnglish (US)
Pages (from-to)1533-1536
Number of pages4
JournalNeural Regeneration Research
Volume10
Issue number10
DOIs
StatePublished - Oct 30 2015

Fingerprint

Spinal Cord Injuries
Sample Size
Tissue Preservation
Weights and Measures
Population
Wounds and Injuries
Research
Therapeutics

Keywords

  • Apoptosis
  • Estrogen
  • Gender
  • Hormone
  • Neuroprotection
  • Progesterone
  • Schwann cell
  • Sex

ASJC Scopus subject areas

  • Developmental Neuroscience

Cite this

Does being female provide a neuroprotective advantage following spinal cord injury? / Datto, Jeffrey P.; Yang, Jackie; Dalton Dietrich, W.; Pearse, Damien D.

In: Neural Regeneration Research, Vol. 10, No. 10, 30.10.2015, p. 1533-1536.

Research output: Contribution to journalArticle

@article{523e870531eb433c8da634ba2fa99b5c,
title = "Does being female provide a neuroprotective advantage following spinal cord injury?",
abstract = "It has been controversial whether gender has any effect on recovery following spinal cord injury (SCI). Past experimental and clinical research aimed at addressing this subject has led to constrasting findings on whether females hold any advantage in locomotor recovery. Additionally, for studies supporting the notion of a female gender related advantage, a definite cause has not been explained. In a recent study, using large sample sizes for comparative male and female spinal cord injury cohorts, we reported that a significant gender advantage favoring females existed in both tissue preservation and functional recovery after taking into consideration discrepancies in age and weight of the animals across sexes. Prior animal research frequently used sample sizes that were too small to determine significance with certainty and also did not account for two other factors that influence locomotor performance: age and weight. Our finding is important in light of controversy surrounding the effect of gender on outcome and the fact that SCI affects more than ten thousand new individuals annually, a population that is disproportionately male. By deepening our understanding of why a gender advantage exists, potential new therapeutics can be designed to improve recovery for the male population following the initial trauma or putatively augment the neuroprotective privilege in females for enhanced outcomes.",
keywords = "Apoptosis, Estrogen, Gender, Hormone, Neuroprotection, Progesterone, Schwann cell, Sex",
author = "Datto, {Jeffrey P.} and Jackie Yang and {Dalton Dietrich}, W. and Pearse, {Damien D}",
year = "2015",
month = "10",
day = "30",
doi = "10.4103/1673-5374.165213",
language = "English (US)",
volume = "10",
pages = "1533--1536",
journal = "Neural Regeneration Research",
issn = "1673-5374",
publisher = "Editorial Board of Neural Regeneration Research",
number = "10",

}

TY - JOUR

T1 - Does being female provide a neuroprotective advantage following spinal cord injury?

AU - Datto, Jeffrey P.

AU - Yang, Jackie

AU - Dalton Dietrich, W.

AU - Pearse, Damien D

PY - 2015/10/30

Y1 - 2015/10/30

N2 - It has been controversial whether gender has any effect on recovery following spinal cord injury (SCI). Past experimental and clinical research aimed at addressing this subject has led to constrasting findings on whether females hold any advantage in locomotor recovery. Additionally, for studies supporting the notion of a female gender related advantage, a definite cause has not been explained. In a recent study, using large sample sizes for comparative male and female spinal cord injury cohorts, we reported that a significant gender advantage favoring females existed in both tissue preservation and functional recovery after taking into consideration discrepancies in age and weight of the animals across sexes. Prior animal research frequently used sample sizes that were too small to determine significance with certainty and also did not account for two other factors that influence locomotor performance: age and weight. Our finding is important in light of controversy surrounding the effect of gender on outcome and the fact that SCI affects more than ten thousand new individuals annually, a population that is disproportionately male. By deepening our understanding of why a gender advantage exists, potential new therapeutics can be designed to improve recovery for the male population following the initial trauma or putatively augment the neuroprotective privilege in females for enhanced outcomes.

AB - It has been controversial whether gender has any effect on recovery following spinal cord injury (SCI). Past experimental and clinical research aimed at addressing this subject has led to constrasting findings on whether females hold any advantage in locomotor recovery. Additionally, for studies supporting the notion of a female gender related advantage, a definite cause has not been explained. In a recent study, using large sample sizes for comparative male and female spinal cord injury cohorts, we reported that a significant gender advantage favoring females existed in both tissue preservation and functional recovery after taking into consideration discrepancies in age and weight of the animals across sexes. Prior animal research frequently used sample sizes that were too small to determine significance with certainty and also did not account for two other factors that influence locomotor performance: age and weight. Our finding is important in light of controversy surrounding the effect of gender on outcome and the fact that SCI affects more than ten thousand new individuals annually, a population that is disproportionately male. By deepening our understanding of why a gender advantage exists, potential new therapeutics can be designed to improve recovery for the male population following the initial trauma or putatively augment the neuroprotective privilege in females for enhanced outcomes.

KW - Apoptosis

KW - Estrogen

KW - Gender

KW - Hormone

KW - Neuroprotection

KW - Progesterone

KW - Schwann cell

KW - Sex

UR - http://www.scopus.com/inward/record.url?scp=84945586936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945586936&partnerID=8YFLogxK

U2 - 10.4103/1673-5374.165213

DO - 10.4103/1673-5374.165213

M3 - Article

AN - SCOPUS:84945586936

VL - 10

SP - 1533

EP - 1536

JO - Neural Regeneration Research

JF - Neural Regeneration Research

SN - 1673-5374

IS - 10

ER -