Does a helicase activity help mismatch repair in eukaryotes?

Limin Song, Fenghua Yuan, Yanbin Zhang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Mismatch repair (MMR) corrects innate DNA replication infidelities. Many components of eukaryotic MMR have been identified, the molecular mechanism of MMR has been largely demonstrated, and furthermore the nick-directed MMR reactions have been reconstituted with purified human proteins in vitro. However, some fundamental questions still remain to be answered. One such question is whether a DNA helicase activity is required for MMR in eukaryotes. This short review presents an overview of the interactions between eukaryotic DNA helicases and MMR factors, and suggests a possible mechanism for how DNA helicases may be involved in repair of DNA ismatches.

Original languageEnglish
Pages (from-to)548-553
Number of pages6
JournalIUBMB Life
Volume62
Issue number7
DOIs
StatePublished - Jul 1 2010

Fingerprint

DNA Mismatch Repair
Eukaryota
Repair
DNA Helicases
DNA Replication
DNA
DNA Repair
Proteins

Keywords

  • DNA helicase
  • DNA mismatch repair
  • Eukaryote
  • Mismatch excision
  • MMR

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Does a helicase activity help mismatch repair in eukaryotes? / Song, Limin; Yuan, Fenghua; Zhang, Yanbin.

In: IUBMB Life, Vol. 62, No. 7, 01.07.2010, p. 548-553.

Research output: Contribution to journalArticle

Song, Limin ; Yuan, Fenghua ; Zhang, Yanbin. / Does a helicase activity help mismatch repair in eukaryotes?. In: IUBMB Life. 2010 ; Vol. 62, No. 7. pp. 548-553.
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