Docetaxel and Carboplatin as First-line Therapy in Advanced Non-small Cell Lung Carcinoma: A Phase II Study

Mohammad Jahanzeb, Greg Sarna, Robert Hirsch, Peter Radice, Alan Koletsky, Manuel Martinez, Elena Kruglyak, Edward Wolin, Elber Camacho, Lori Kronish, Susannah Motl

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: Taxanes have been widely used against advanced non-small cell lung cancer (NSCLC), alone and in combination with platinum agents. In order to develop a tolerable palliative regimen, we combined carboplatin with low dose docetaxel. Patients and Methods: Chemotherapy-naive patients, with Stage IIIB or IV NSCLC and an ECOG performance status ≤2, were enrolled Treatment consisted of docetaxel 60 mg/m2 and carboplatin AUC 6 every 21 days. Therapy continued for 1 year or 6 months beyond best response, whichever was greater. Results: Twenty-five patients were enrolled. Most patients (80%) had Stage IV disease. The partial response rate was 16%. Response duration ranged from 6 to 115 weeks. Median survival was 55 weeks. Toxicity was generally limited to grade 3 or 4 neutropenia. There was 1 septic death. Conclusion: Survival compared favorably to other similar trials employing higher doses of docetaxel Additionally, a hematologic toxicity advantage was seen compared to regimens containing higher doses of docetaxel.

Original languageEnglish (US)
Pages (from-to)1239-1242
Number of pages4
JournalAnticancer research
Volume24
Issue number2 C
StatePublished - Mar 1 2004
Externally publishedYes

Keywords

  • Carboplatin
  • Docetaxel
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Jahanzeb, M., Sarna, G., Hirsch, R., Radice, P., Koletsky, A., Martinez, M., Kruglyak, E., Wolin, E., Camacho, E., Kronish, L., & Motl, S. (2004). Docetaxel and Carboplatin as First-line Therapy in Advanced Non-small Cell Lung Carcinoma: A Phase II Study. Anticancer research, 24(2 C), 1239-1242.