Do vervets and macaques respond differently to BMAA?

Paul Alan Cox, David A. Davis, Deborah C Mash, James S. Metcalf, Sandra Anne Banack

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Vervets with chronic dietary exposure to BMAA develop neurofibrillary tangles (NFT) and sparse β-amyloid plaque-like deposits in the brain. Macaques dosed via oral gavage with BMAA developed marked neurological signs in the absence of cell death. These differences may result from increased vulnerability of macaques to BMAA, the higher effective dose they received via oral gavage, and the possibility of stable adducts due to the bicarbonate used to neutralize their BMAA dose. Confirmation of chromatolysis and cell death in macaque brains was visualized using toluidine staining. In contrast, immunological staining with AT8 and β-amyloid (1-42) antibodies and thioflavine-S stain in vervet brains suggests early stage labeling of neurites and NFT and plaque-like formation in the absence of neuronal loss. The lack of neurologic deficits reported in vervets is in keeping with early preclinical pathology observed with these immunohistochemical methods. BMAA toxicity in vervet brains causes the early events that occur in the genesis of neurofibrillary pathology. Taken together, these different studies of vervets and macaques demonstrate BMAA toxicity in the brain due to chronic exposures. The use of more sensitive immunohistochemical methods in the vervet study most likely explains the differences in neuropathology reported for vervets and macaques.

Original languageEnglish (US)
JournalNeuroToxicology
DOIs
StateAccepted/In press - 2016

Keywords

  • Beta-amyloid
  • BMAA
  • Hyperphosphorylation
  • Macaques
  • Neurofibrillary tangles
  • Neuropathology
  • Thioflavin
  • Vervets

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

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    Cox, P. A., Davis, D. A., Mash, D. C., Metcalf, J. S., & Banack, S. A. (Accepted/In press). Do vervets and macaques respond differently to BMAA? NeuroToxicology. https://doi.org/10.1016/j.neuro.2016.04.017