Do racial or socioeconomic disparities exist in lung cancer treatment?

Relin Yang, Michael C. Cheung, Margaret M Byrne, Youjie Huang, Dao Nguyen, Brian E. Lally, Leonidas G. Koniaris

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

BACKGROUND: Determine the effects of race, socioeconomic status, and treatment on outcomes for patients diagnosed with lung cancer. METHODS: The Florida cancer registry and inpatient and ambulatory data were queried for patients diagnosed from 1998-2002. RESULTS: A total 76,086 of lung cancer patients were identified. Overall, 55.6% were male and 44.4% were female. The demographic distribution of patients was 92.7% Caucasian, 6.7% African American, and 5.7% Hispanic. The mean age of diagnosis was 70 years old. African American patients presented at a younger age, with more advanced disease, and were less likely to undergo surgical therapy than their Caucasian counterparts. Median survival time (MST) for the entire cohort was 8.7 months, while MST for African American patients was 7.5 months. Patients who received surgery, chemotherapy, or radiation therapy demonstrated significantly improved outcomes. Stepwise multivariate analysis revealed that African American race was no longer a statistically significant predictor of worse outcomes once corrections were made for demographics and comorbid conditions, suggesting that the originally reported disparities in lung cancer outcomes and race may be in part because of poor pretreatment performance status. In contrast, patients of the lowest socioeconomic status continue to have a slightly worse overall prognosis than their affluent counterparts (hazard ratio = 1.05, P = .001). CONCLUSIONS: Lung cancer continues to carry a poor prognosis for all patients. Once comorbidities are corrected for, African American patients carry equivalently poor outcomes. Nonetheless, emphasis must be placed on improving pretreatment performance status among African American patients and efforts for earlier diagnosis among the impoverished patients must be made.

Original languageEnglish
Pages (from-to)2437-2447
Number of pages11
JournalCancer
Volume116
Issue number10
DOIs
StatePublished - May 15 2010

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Lung Neoplasms
African Americans
Therapeutics
Social Class
Demography
Survival
Hispanic Americans
Registries
Comorbidity
Inpatients
Early Diagnosis
Radiotherapy
Multivariate Analysis
Drug Therapy

Keywords

  • Disparity
  • Lung cancer
  • Outcomes
  • Race
  • Socioeconomic status

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Yang, R., Cheung, M. C., Byrne, M. M., Huang, Y., Nguyen, D., Lally, B. E., & Koniaris, L. G. (2010). Do racial or socioeconomic disparities exist in lung cancer treatment? Cancer, 116(10), 2437-2447. https://doi.org/10.1002/cncr.24986

Do racial or socioeconomic disparities exist in lung cancer treatment? / Yang, Relin; Cheung, Michael C.; Byrne, Margaret M; Huang, Youjie; Nguyen, Dao; Lally, Brian E.; Koniaris, Leonidas G.

In: Cancer, Vol. 116, No. 10, 15.05.2010, p. 2437-2447.

Research output: Contribution to journalArticle

Yang, R, Cheung, MC, Byrne, MM, Huang, Y, Nguyen, D, Lally, BE & Koniaris, LG 2010, 'Do racial or socioeconomic disparities exist in lung cancer treatment?', Cancer, vol. 116, no. 10, pp. 2437-2447. https://doi.org/10.1002/cncr.24986
Yang R, Cheung MC, Byrne MM, Huang Y, Nguyen D, Lally BE et al. Do racial or socioeconomic disparities exist in lung cancer treatment? Cancer. 2010 May 15;116(10):2437-2447. https://doi.org/10.1002/cncr.24986
Yang, Relin ; Cheung, Michael C. ; Byrne, Margaret M ; Huang, Youjie ; Nguyen, Dao ; Lally, Brian E. ; Koniaris, Leonidas G. / Do racial or socioeconomic disparities exist in lung cancer treatment?. In: Cancer. 2010 ; Vol. 116, No. 10. pp. 2437-2447.
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