Do mitochondrial DNA haplogroups play a role in susceptibility to tuberculosis?

Massoud Houshmand, Mohammad Mehdi Banoei, Payam Tabarsi, Mehdi Shafa Shariat Panahi, Baharak Hooshiar Kashani, Golnaz Ebrahimi, Laleh Zargar, Parissa Farnia, Matthew W. Morris, Davood Mansouri, Ali Akbar Velayati, Mehdi S. Mirsaeidi

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background and objectives: Mitochondrial DNA has a unique role in ATP production and subsequent mitochondrial reactive oxygen species (ROS) production in eukaryotic cells and there is a potential role for ROS and oxygen burst against Mycobacterium tuberculosis, an intracellular pathogen. This study aimed to determine whether the frequency of different mitochondrial haplogroups was significantly different in patients with tuberculosis (TB) compared with a normal population. Methods: Mitochondrial DNA haplogroups M, N, J and K were studied by PCR-restriction fragment length polymorphism and sequencing. Cases were 54 patients with confirmed smear positive pulmonary TB. Controls were 256 healthy persons. Results: There were no statistically significant differences between those with TB and the control group. Conclusions: There was no statistically significant association between mtDNA haplogroups and the presence of TB infection.

Original languageEnglish (US)
Pages (from-to)823-827
Number of pages5
JournalRespirology
Volume12
Issue number6
DOIs
StatePublished - Nov 1 2007
Externally publishedYes

Keywords

  • Haplogroups
  • Mitochondria
  • Susceptibility
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Do mitochondrial DNA haplogroups play a role in susceptibility to tuberculosis?'. Together they form a unique fingerprint.

  • Cite this

    Houshmand, M., Banoei, M. M., Tabarsi, P., Panahi, M. S. S., Kashani, B. H., Ebrahimi, G., Zargar, L., Farnia, P., Morris, M. W., Mansouri, D., Velayati, A. A., & Mirsaeidi, M. S. (2007). Do mitochondrial DNA haplogroups play a role in susceptibility to tuberculosis? Respirology, 12(6), 823-827. https://doi.org/10.1111/j.1440-1843.2007.01163.x