Do histologic criteria predict biologic behavior of giant cell lesions?

Zachary S. Peacock, Cory M. Resnick, Srinivas M. Susarla, William C. Faquin, Andrew Rosenberg, Gunnlaugur P. Nielsen, Joseph H. Schwab, Francis Hornicek, David H. Ebb, Thomas B. Dodson, Leonard B. Kaban

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: To determine whether the clinical behavior of giant cell lesions (GCLs) or their anatomic location can be differentiated by histologic criteria alone. Materials and Methods: We performed a retrospective study of patients with GCLs treated at Massachusetts General Hospital between 1993 and 2008. Predictor variables were histologic parameters: number of giant cells (GCs) per high-power field, number of nuclei per GC, GC size, stromal cellularity, stromal type, presence of hemorrhage and reactive osteoid, and blinded pathologists' prediction of location and behavior. Outcome variables were clinical behavior (aggressive or nonaggressive) and GCL location, that is, maxillofacial (MF) or axial/appendicular (AA). Descriptive and bivariate statistics were computed with statistical significance set at P ≤.05. Results: The sample included 88 subjects: 41 MF GCLs (35 aggressive) and 47 AA GCLs (28 aggressive). Aggressive AA lesions had more GCs per high-power field, larger mean GC size, and increased stromal cellularity, and they more frequently had a mononuclear stroma when compared with aggressive MF lesions (P <.05). There were no significant histologic differences between aggressive and nonaggressive MF lesions or between nonaggressive MF and nonaggressive AA lesions. Aggressive AA lesions had more nuclei/GC than nonaggressive AA lesions (P =.03). Using histologic criteria only, blinded pathologists predicted clinical behavior in only 45% of cases (κ = 0.19, P =.09). They predicted a lesion's location in 82% of cases with fair agreement (κ = 0.44, P <.01). Conclusions: Results of this study indicate that histologic differences between aggressive and nonaggressive GCLs are insufficient for pathologists to differentiate them consistently regardless of location.

Original languageEnglish
Pages (from-to)2573-2580
Number of pages8
JournalJournal of Oral and Maxillofacial Surgery
Volume70
Issue number11
DOIs
StatePublished - Nov 1 2012
Externally publishedYes

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Giant Cells
Cell Size
General Hospitals
Retrospective Studies
Hemorrhage

ASJC Scopus subject areas

  • Oral Surgery
  • Otorhinolaryngology
  • Surgery

Cite this

Peacock, Z. S., Resnick, C. M., Susarla, S. M., Faquin, W. C., Rosenberg, A., Nielsen, G. P., ... Kaban, L. B. (2012). Do histologic criteria predict biologic behavior of giant cell lesions? Journal of Oral and Maxillofacial Surgery, 70(11), 2573-2580. https://doi.org/10.1016/j.joms.2011.12.005

Do histologic criteria predict biologic behavior of giant cell lesions? / Peacock, Zachary S.; Resnick, Cory M.; Susarla, Srinivas M.; Faquin, William C.; Rosenberg, Andrew; Nielsen, Gunnlaugur P.; Schwab, Joseph H.; Hornicek, Francis; Ebb, David H.; Dodson, Thomas B.; Kaban, Leonard B.

In: Journal of Oral and Maxillofacial Surgery, Vol. 70, No. 11, 01.11.2012, p. 2573-2580.

Research output: Contribution to journalArticle

Peacock, ZS, Resnick, CM, Susarla, SM, Faquin, WC, Rosenberg, A, Nielsen, GP, Schwab, JH, Hornicek, F, Ebb, DH, Dodson, TB & Kaban, LB 2012, 'Do histologic criteria predict biologic behavior of giant cell lesions?', Journal of Oral and Maxillofacial Surgery, vol. 70, no. 11, pp. 2573-2580. https://doi.org/10.1016/j.joms.2011.12.005
Peacock, Zachary S. ; Resnick, Cory M. ; Susarla, Srinivas M. ; Faquin, William C. ; Rosenberg, Andrew ; Nielsen, Gunnlaugur P. ; Schwab, Joseph H. ; Hornicek, Francis ; Ebb, David H. ; Dodson, Thomas B. ; Kaban, Leonard B. / Do histologic criteria predict biologic behavior of giant cell lesions?. In: Journal of Oral and Maxillofacial Surgery. 2012 ; Vol. 70, No. 11. pp. 2573-2580.
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abstract = "Purpose: To determine whether the clinical behavior of giant cell lesions (GCLs) or their anatomic location can be differentiated by histologic criteria alone. Materials and Methods: We performed a retrospective study of patients with GCLs treated at Massachusetts General Hospital between 1993 and 2008. Predictor variables were histologic parameters: number of giant cells (GCs) per high-power field, number of nuclei per GC, GC size, stromal cellularity, stromal type, presence of hemorrhage and reactive osteoid, and blinded pathologists' prediction of location and behavior. Outcome variables were clinical behavior (aggressive or nonaggressive) and GCL location, that is, maxillofacial (MF) or axial/appendicular (AA). Descriptive and bivariate statistics were computed with statistical significance set at P ≤.05. Results: The sample included 88 subjects: 41 MF GCLs (35 aggressive) and 47 AA GCLs (28 aggressive). Aggressive AA lesions had more GCs per high-power field, larger mean GC size, and increased stromal cellularity, and they more frequently had a mononuclear stroma when compared with aggressive MF lesions (P <.05). There were no significant histologic differences between aggressive and nonaggressive MF lesions or between nonaggressive MF and nonaggressive AA lesions. Aggressive AA lesions had more nuclei/GC than nonaggressive AA lesions (P =.03). Using histologic criteria only, blinded pathologists predicted clinical behavior in only 45{\%} of cases (κ = 0.19, P =.09). They predicted a lesion's location in 82{\%} of cases with fair agreement (κ = 0.44, P <.01). Conclusions: Results of this study indicate that histologic differences between aggressive and nonaggressive GCLs are insufficient for pathologists to differentiate them consistently regardless of location.",
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T1 - Do histologic criteria predict biologic behavior of giant cell lesions?

AU - Peacock, Zachary S.

AU - Resnick, Cory M.

AU - Susarla, Srinivas M.

AU - Faquin, William C.

AU - Rosenberg, Andrew

AU - Nielsen, Gunnlaugur P.

AU - Schwab, Joseph H.

AU - Hornicek, Francis

AU - Ebb, David H.

AU - Dodson, Thomas B.

AU - Kaban, Leonard B.

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N2 - Purpose: To determine whether the clinical behavior of giant cell lesions (GCLs) or their anatomic location can be differentiated by histologic criteria alone. Materials and Methods: We performed a retrospective study of patients with GCLs treated at Massachusetts General Hospital between 1993 and 2008. Predictor variables were histologic parameters: number of giant cells (GCs) per high-power field, number of nuclei per GC, GC size, stromal cellularity, stromal type, presence of hemorrhage and reactive osteoid, and blinded pathologists' prediction of location and behavior. Outcome variables were clinical behavior (aggressive or nonaggressive) and GCL location, that is, maxillofacial (MF) or axial/appendicular (AA). Descriptive and bivariate statistics were computed with statistical significance set at P ≤.05. Results: The sample included 88 subjects: 41 MF GCLs (35 aggressive) and 47 AA GCLs (28 aggressive). Aggressive AA lesions had more GCs per high-power field, larger mean GC size, and increased stromal cellularity, and they more frequently had a mononuclear stroma when compared with aggressive MF lesions (P <.05). There were no significant histologic differences between aggressive and nonaggressive MF lesions or between nonaggressive MF and nonaggressive AA lesions. Aggressive AA lesions had more nuclei/GC than nonaggressive AA lesions (P =.03). Using histologic criteria only, blinded pathologists predicted clinical behavior in only 45% of cases (κ = 0.19, P =.09). They predicted a lesion's location in 82% of cases with fair agreement (κ = 0.44, P <.01). Conclusions: Results of this study indicate that histologic differences between aggressive and nonaggressive GCLs are insufficient for pathologists to differentiate them consistently regardless of location.

AB - Purpose: To determine whether the clinical behavior of giant cell lesions (GCLs) or their anatomic location can be differentiated by histologic criteria alone. Materials and Methods: We performed a retrospective study of patients with GCLs treated at Massachusetts General Hospital between 1993 and 2008. Predictor variables were histologic parameters: number of giant cells (GCs) per high-power field, number of nuclei per GC, GC size, stromal cellularity, stromal type, presence of hemorrhage and reactive osteoid, and blinded pathologists' prediction of location and behavior. Outcome variables were clinical behavior (aggressive or nonaggressive) and GCL location, that is, maxillofacial (MF) or axial/appendicular (AA). Descriptive and bivariate statistics were computed with statistical significance set at P ≤.05. Results: The sample included 88 subjects: 41 MF GCLs (35 aggressive) and 47 AA GCLs (28 aggressive). Aggressive AA lesions had more GCs per high-power field, larger mean GC size, and increased stromal cellularity, and they more frequently had a mononuclear stroma when compared with aggressive MF lesions (P <.05). There were no significant histologic differences between aggressive and nonaggressive MF lesions or between nonaggressive MF and nonaggressive AA lesions. Aggressive AA lesions had more nuclei/GC than nonaggressive AA lesions (P =.03). Using histologic criteria only, blinded pathologists predicted clinical behavior in only 45% of cases (κ = 0.19, P =.09). They predicted a lesion's location in 82% of cases with fair agreement (κ = 0.44, P <.01). Conclusions: Results of this study indicate that histologic differences between aggressive and nonaggressive GCLs are insufficient for pathologists to differentiate them consistently regardless of location.

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