Do active cerebral neurons really use lactate rather than glucose?

Ching Ping Chih, Peter Lipton, Eugene L Roberts

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

Glucose has long been considered the substrate for neuronal energy metabolism in the brain. Recently, an alternative explanation of energy metabolism in the active brain, the astrocyte-neuron lactate shuttle hypothesis, has received attention. It suggests that during neural activity energy needs in glia are met by anaerobic glycolysis, whereas neuronal metabolism is fueled by lactate released from glia. In this article, we critically examine the evidence supporting this hypothesis and explain, from the perspective of enzyme kinetics and substrate availability, why neurons probably use ambient glucose, and not glial-derived lactate, as the major substrate during activity.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalTrends in Neurosciences
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2001

Fingerprint

Neuroglia
Lactic Acid
Neurons
Glucose
Energy Metabolism
Brain
Glycolysis
Astrocytes
Enzymes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Do active cerebral neurons really use lactate rather than glucose? / Chih, Ching Ping; Lipton, Peter; Roberts, Eugene L.

In: Trends in Neurosciences, Vol. 24, No. 10, 01.10.2001, p. 573-578.

Research output: Contribution to journalArticle

Chih, Ching Ping ; Lipton, Peter ; Roberts, Eugene L. / Do active cerebral neurons really use lactate rather than glucose?. In: Trends in Neurosciences. 2001 ; Vol. 24, No. 10. pp. 573-578.
@article{759d575684c543ec9e5b29f718599b92,
title = "Do active cerebral neurons really use lactate rather than glucose?",
abstract = "Glucose has long been considered the substrate for neuronal energy metabolism in the brain. Recently, an alternative explanation of energy metabolism in the active brain, the astrocyte-neuron lactate shuttle hypothesis, has received attention. It suggests that during neural activity energy needs in glia are met by anaerobic glycolysis, whereas neuronal metabolism is fueled by lactate released from glia. In this article, we critically examine the evidence supporting this hypothesis and explain, from the perspective of enzyme kinetics and substrate availability, why neurons probably use ambient glucose, and not glial-derived lactate, as the major substrate during activity.",
author = "Chih, {Ching Ping} and Peter Lipton and Roberts, {Eugene L}",
year = "2001",
month = "10",
day = "1",
doi = "10.1016/S0166-2236(00)01920-2",
language = "English",
volume = "24",
pages = "573--578",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "10",

}

TY - JOUR

T1 - Do active cerebral neurons really use lactate rather than glucose?

AU - Chih, Ching Ping

AU - Lipton, Peter

AU - Roberts, Eugene L

PY - 2001/10/1

Y1 - 2001/10/1

N2 - Glucose has long been considered the substrate for neuronal energy metabolism in the brain. Recently, an alternative explanation of energy metabolism in the active brain, the astrocyte-neuron lactate shuttle hypothesis, has received attention. It suggests that during neural activity energy needs in glia are met by anaerobic glycolysis, whereas neuronal metabolism is fueled by lactate released from glia. In this article, we critically examine the evidence supporting this hypothesis and explain, from the perspective of enzyme kinetics and substrate availability, why neurons probably use ambient glucose, and not glial-derived lactate, as the major substrate during activity.

AB - Glucose has long been considered the substrate for neuronal energy metabolism in the brain. Recently, an alternative explanation of energy metabolism in the active brain, the astrocyte-neuron lactate shuttle hypothesis, has received attention. It suggests that during neural activity energy needs in glia are met by anaerobic glycolysis, whereas neuronal metabolism is fueled by lactate released from glia. In this article, we critically examine the evidence supporting this hypothesis and explain, from the perspective of enzyme kinetics and substrate availability, why neurons probably use ambient glucose, and not glial-derived lactate, as the major substrate during activity.

UR - http://www.scopus.com/inward/record.url?scp=0035478762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035478762&partnerID=8YFLogxK

U2 - 10.1016/S0166-2236(00)01920-2

DO - 10.1016/S0166-2236(00)01920-2

M3 - Article

C2 - 11576670

AN - SCOPUS:0035478762

VL - 24

SP - 573

EP - 578

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 10

ER -