DNA mismatch repair and the DNA damage response to ionizing radiation: Making sense of apparently conflicting data

Lynn M. Martin, Brian Marples, Mary Coffey, Mark Lawler, Thomas H. Lynch, Donal Hollywood, Laure Marignol

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

The DNA mismatch repair (MMR) pathway detects and repairs DNA replication errors. While DNA MMR-proficiency is known to play a key role in the sensitivity to a number of DNA damaging agents, its role in the cytotoxicity of ionizing radiation (IR) is less well characterized. Available literature to date is conflicting regarding the influence of MMR status on radiosensitivity, and this has arisen as a subject of controversy in the field. The aim of this paper is to provide the first comprehensive overview of the experimental data linking MMR proteins and the DNA damage response to IR. A PubMed search was conducted using the key words " DNA mismatch repair" and " ionizing radiation" Relevant articles and their references were reviewed for their association between DNA MMR and IR. Recent data suggest that radiation dose and the type of DNA damage induced may dictate the involvement of the MMR system in the cellular response to IR. In particular, the literature supports a role for the MMR system in DNA damage recognition, cell cycle arrest, DNA repair and apoptosis. In this review we discuss our current understanding of the impact of MMR status on the cellular response to radiation in mammalian cells gained from past and present studies and attempt to provide an explanation for how MMR may determine the response to radiation.

Original languageEnglish (US)
Pages (from-to)518-527
Number of pages10
JournalCancer Treatment Reviews
Volume36
Issue number7
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

Fingerprint

DNA Mismatch Repair
Ionizing Radiation
DNA Damage
Radiation
Radiation Tolerance
Cell Cycle Checkpoints
DNA Replication
PubMed
DNA Repair
Apoptosis

Keywords

  • Cell cycle arrest
  • DNA mismatch repair
  • G2/M
  • Hypersensitivity
  • Ionizing radiation
  • Low dose
  • MLH1
  • MSH2
  • RAD51
  • Review

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

DNA mismatch repair and the DNA damage response to ionizing radiation : Making sense of apparently conflicting data. / Martin, Lynn M.; Marples, Brian; Coffey, Mary; Lawler, Mark; Lynch, Thomas H.; Hollywood, Donal; Marignol, Laure.

In: Cancer Treatment Reviews, Vol. 36, No. 7, 01.11.2010, p. 518-527.

Research output: Contribution to journalReview article

Martin, Lynn M. ; Marples, Brian ; Coffey, Mary ; Lawler, Mark ; Lynch, Thomas H. ; Hollywood, Donal ; Marignol, Laure. / DNA mismatch repair and the DNA damage response to ionizing radiation : Making sense of apparently conflicting data. In: Cancer Treatment Reviews. 2010 ; Vol. 36, No. 7. pp. 518-527.
@article{19c67ee63ba344fb813b95e1b2785d0e,
title = "DNA mismatch repair and the DNA damage response to ionizing radiation: Making sense of apparently conflicting data",
abstract = "The DNA mismatch repair (MMR) pathway detects and repairs DNA replication errors. While DNA MMR-proficiency is known to play a key role in the sensitivity to a number of DNA damaging agents, its role in the cytotoxicity of ionizing radiation (IR) is less well characterized. Available literature to date is conflicting regarding the influence of MMR status on radiosensitivity, and this has arisen as a subject of controversy in the field. The aim of this paper is to provide the first comprehensive overview of the experimental data linking MMR proteins and the DNA damage response to IR. A PubMed search was conducted using the key words {"} DNA mismatch repair{"} and {"} ionizing radiation{"} Relevant articles and their references were reviewed for their association between DNA MMR and IR. Recent data suggest that radiation dose and the type of DNA damage induced may dictate the involvement of the MMR system in the cellular response to IR. In particular, the literature supports a role for the MMR system in DNA damage recognition, cell cycle arrest, DNA repair and apoptosis. In this review we discuss our current understanding of the impact of MMR status on the cellular response to radiation in mammalian cells gained from past and present studies and attempt to provide an explanation for how MMR may determine the response to radiation.",
keywords = "Cell cycle arrest, DNA mismatch repair, G2/M, Hypersensitivity, Ionizing radiation, Low dose, MLH1, MSH2, RAD51, Review",
author = "Martin, {Lynn M.} and Brian Marples and Mary Coffey and Mark Lawler and Lynch, {Thomas H.} and Donal Hollywood and Laure Marignol",
year = "2010",
month = "11",
day = "1",
doi = "10.1016/j.ctrv.2010.03.008",
language = "English (US)",
volume = "36",
pages = "518--527",
journal = "Cancer Treatment Reviews",
issn = "0305-7372",
publisher = "W.B. Saunders Ltd",
number = "7",

}

TY - JOUR

T1 - DNA mismatch repair and the DNA damage response to ionizing radiation

T2 - Making sense of apparently conflicting data

AU - Martin, Lynn M.

AU - Marples, Brian

AU - Coffey, Mary

AU - Lawler, Mark

AU - Lynch, Thomas H.

AU - Hollywood, Donal

AU - Marignol, Laure

PY - 2010/11/1

Y1 - 2010/11/1

N2 - The DNA mismatch repair (MMR) pathway detects and repairs DNA replication errors. While DNA MMR-proficiency is known to play a key role in the sensitivity to a number of DNA damaging agents, its role in the cytotoxicity of ionizing radiation (IR) is less well characterized. Available literature to date is conflicting regarding the influence of MMR status on radiosensitivity, and this has arisen as a subject of controversy in the field. The aim of this paper is to provide the first comprehensive overview of the experimental data linking MMR proteins and the DNA damage response to IR. A PubMed search was conducted using the key words " DNA mismatch repair" and " ionizing radiation" Relevant articles and their references were reviewed for their association between DNA MMR and IR. Recent data suggest that radiation dose and the type of DNA damage induced may dictate the involvement of the MMR system in the cellular response to IR. In particular, the literature supports a role for the MMR system in DNA damage recognition, cell cycle arrest, DNA repair and apoptosis. In this review we discuss our current understanding of the impact of MMR status on the cellular response to radiation in mammalian cells gained from past and present studies and attempt to provide an explanation for how MMR may determine the response to radiation.

AB - The DNA mismatch repair (MMR) pathway detects and repairs DNA replication errors. While DNA MMR-proficiency is known to play a key role in the sensitivity to a number of DNA damaging agents, its role in the cytotoxicity of ionizing radiation (IR) is less well characterized. Available literature to date is conflicting regarding the influence of MMR status on radiosensitivity, and this has arisen as a subject of controversy in the field. The aim of this paper is to provide the first comprehensive overview of the experimental data linking MMR proteins and the DNA damage response to IR. A PubMed search was conducted using the key words " DNA mismatch repair" and " ionizing radiation" Relevant articles and their references were reviewed for their association between DNA MMR and IR. Recent data suggest that radiation dose and the type of DNA damage induced may dictate the involvement of the MMR system in the cellular response to IR. In particular, the literature supports a role for the MMR system in DNA damage recognition, cell cycle arrest, DNA repair and apoptosis. In this review we discuss our current understanding of the impact of MMR status on the cellular response to radiation in mammalian cells gained from past and present studies and attempt to provide an explanation for how MMR may determine the response to radiation.

KW - Cell cycle arrest

KW - DNA mismatch repair

KW - G2/M

KW - Hypersensitivity

KW - Ionizing radiation

KW - Low dose

KW - MLH1

KW - MSH2

KW - RAD51

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=77957948991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957948991&partnerID=8YFLogxK

U2 - 10.1016/j.ctrv.2010.03.008

DO - 10.1016/j.ctrv.2010.03.008

M3 - Review article

C2 - 20413225

AN - SCOPUS:77957948991

VL - 36

SP - 518

EP - 527

JO - Cancer Treatment Reviews

JF - Cancer Treatment Reviews

SN - 0305-7372

IS - 7

ER -