DNA methylation: Its role in lung carcinogenesis and therapeutic implications

Edgardo S. Santos, Luis E. Raez, Teresa DeCesare, Rakesh Singal

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

A new era in the treatment of malignant diseases has been observed through the use of biologic agents targeting growth factor receptors, signaling pathways, gene mutations and others. The results have been impressive in some diseases and modest in others. The discovery of new targets has expanded our knowledge of different mechanisms in tumorigenesis. One of these mechanisms has been DNA methylation, which is an important gene transcription regulator. Although the role of methylation in lung carcinogenesis is not well understood, there is an enormous quantity of evolving data suggesting its critical role in lung cancer. In this review, the authors will discuss methylation in lung carcinogenesis and its possible clinical implications.

Original languageEnglish (US)
Pages (from-to)667-679
Number of pages13
JournalExpert review of anticancer therapy
Volume5
Issue number4
DOIs
StatePublished - Aug 1 2005

Keywords

  • Carcinogenesis
  • CpG island
  • DNA methylation
  • Epigenetic
  • Gene silencing
  • Histone deacetylase inhibitor
  • Hypermethylation
  • Non-small cell lung cancer
  • Promoter methylation

ASJC Scopus subject areas

  • Pharmacology
  • Cancer Research

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