DNA methylation dynamics and cocaine in the brain: Progress and prospects

Kathryn Vaillancourt, Carl Ernst, Deborah Mash, Gustavo Turecki

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Cytosine modifications, including DNA methylation, are stable epigenetic marks that may translate environmental change into transcriptional regulation. Research has begun to investigate DNA methylation dynamics in relation to cocaine use disorders. Specifically, DNA methylation machinery, including methyltransferases and binding proteins, are dysregulated in brain reward pathways after chronic cocaine exposure. In addition, numerous methylome-wide and candidate promoter studies have identified differential methylation, at the nucleotide level, in rodent models of cocaine abuse and drug seeking behavior. This review highlights the current progress in the field of cocaine-related methylation, and offers considerations for future research.

Original languageEnglish (US)
Article number138
JournalGenes
Volume8
Issue number5
DOIs
StatePublished - May 12 2017

Keywords

  • Addiction
  • Cocaine
  • DNA methylation
  • Epigenetics

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Vaillancourt, K., Ernst, C., Mash, D., & Turecki, G. (2017). DNA methylation dynamics and cocaine in the brain: Progress and prospects. Genes, 8(5), [138]. https://doi.org/10.3390/genes8050138