DNA methylation and atherosclerosis

Chunming Dong, Woohyun Yoon, Pascal Goldschmidt-Clermont

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

DNA methylation is a major epigenetic modification of the genome that has the potential to silence gene expression. Recently, the role of epigenetic alteration as a distinct and crucial mechanism to regulate genes governing cell proliferation in atherosclerosis has emerged. Aberrant methylation is related to aging, and, because it affects a large number of CpG islands, age-related methylation may be an important contributor to increased atherosclerosis among older individuals by upregulating atherosclerosis-susceptible genes and downregulating atherosclerosis-protective genes. Further dissection of epigenetic alterations in atherosclerosis and aging will lead to the identification of novel epigenetic modifiers and improved diagnosis and treatment for atherosclerosis-related diseases.

Original languageEnglish
JournalJournal of Nutrition
Volume132
Issue number8 SUPPL.
StatePublished - Aug 15 2002
Externally publishedYes

Fingerprint

DNA methylation
DNA Methylation
atherosclerosis
Atherosclerosis
Epigenomics
epigenetics
methylation
Methylation
Genes
CpG Islands
modifiers (genes)
genes
Dissection
cell proliferation
Down-Regulation
Cell Proliferation
Genome
Gene Expression
gene expression
genome

Keywords

  • Aging
  • Atherosclerosis
  • DNA methylation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Dong, C., Yoon, W., & Goldschmidt-Clermont, P. (2002). DNA methylation and atherosclerosis. Journal of Nutrition, 132(8 SUPPL.).

DNA methylation and atherosclerosis. / Dong, Chunming; Yoon, Woohyun; Goldschmidt-Clermont, Pascal.

In: Journal of Nutrition, Vol. 132, No. 8 SUPPL., 15.08.2002.

Research output: Contribution to journalArticle

Dong, C, Yoon, W & Goldschmidt-Clermont, P 2002, 'DNA methylation and atherosclerosis', Journal of Nutrition, vol. 132, no. 8 SUPPL..
Dong C, Yoon W, Goldschmidt-Clermont P. DNA methylation and atherosclerosis. Journal of Nutrition. 2002 Aug 15;132(8 SUPPL.).
Dong, Chunming ; Yoon, Woohyun ; Goldschmidt-Clermont, Pascal. / DNA methylation and atherosclerosis. In: Journal of Nutrition. 2002 ; Vol. 132, No. 8 SUPPL.
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