DNA methylation and atherosclerosis

Chunming Dong, Woohyun Yoon, Pascal J. Goldschmidt-Clermont

Research output: Contribution to journalArticle

127 Scopus citations

Abstract

DNA methylation is a major epigenetic modification of the genome that has the potential to silence gene expression. Recently, the role of epigenetic alteration as a distinct and crucial mechanism to regulate genes governing cell proliferation in atherosclerosis has emerged. Aberrant methylation is related to aging, and, because it affects a large number of CpG islands, age-related methylation may be an important contributor to increased atherosclerosis among older individuals by upregulating atherosclerosis-susceptible genes and downregulating atherosclerosis-protective genes. Further dissection of epigenetic alterations in atherosclerosis and aging will lead to the identification of novel epigenetic modifiers and improved diagnosis and treatment for atherosclerosis-related diseases.

Original languageEnglish (US)
Pages (from-to)2406S-2409S
JournalJournal of Nutrition
Volume132
Issue number8 SUPPL.
DOIs
StatePublished - 2002

Keywords

  • Aging
  • Atherosclerosis
  • DNA methylation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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    Dong, C., Yoon, W., & Goldschmidt-Clermont, P. J. (2002). DNA methylation and atherosclerosis. Journal of Nutrition, 132(8 SUPPL.), 2406S-2409S. https://doi.org/10.1093/jn/132.8.2406s