DNA-dependent-DNA-polymerase: Possible limiting influence on cell reproduction during viral leukemogenesis

J. P. OKunewick, P. G. Braunschweiger

Research output: Contribution to journalArticlepeer-review

Abstract

Evidence is presented that during viral leukemogenesis spleen cell nuclei show an increase in labelling index and mean grain count, that is not accompanied by any changes in the nuclear level of DNA-polymerase-α. It is suggested that polymerase production remains under the control of the normal cell mechanisms and the virus may affect cell proliferation by altering the primer-template levels.

Original languageEnglish (US)
Pages (from-to)108-109
Number of pages2
JournalExperientia
Volume34
Issue number1
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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