DNA damage and chronic neuronal degenerations

Steven H. Robison, Walter G. Bradley

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

DNA plays an essential role not only in dividing cells, but also in postmitotic cells such as neurons. Accumulated damage to the nuclear DNA will result in damage to neuronal metabolism. There is suggestive evidence of altered DNA in ALS, Alzheimer's and Parkinson's diseases, and of deficiency of DNA repair mechanisms in these age-related neuronal degenerations and in Huntington's disease. We suggest that these DNA abnormalities are more likely to be the cause of the diseases, rather than an effect of the disease process.

Original languageEnglish (US)
Pages (from-to)11-20
Number of pages10
JournalJournal of the Neurological Sciences
Volume64
Issue number1
DOIs
StatePublished - Apr 1984

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Keywords

  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Chronic neuronal degenerations
  • DNA
  • Huntington's disease
  • Neuronal metabolism
  • Neurons
  • Parkinson's disease

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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