Abstract
This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www.helsinki.fi/~1g1-www/CMG.html. The genes relevant to the lost regions are discussed for each of the chromosomes. The review is supplemented also by a list of known and putative tumor suppressor genes and DNA repair genes (see Table 1, online). Losses are found in all chromosome arms, but they seem to be relatively rare at 1q, 2p, 3q, 5p, 6p, 7p, 7q, 8q, 12p, and 20q. Losses and their minimal common overlapping areas that were present in a great proportion of the 73 tumor entities reported in Table 2 (see online) are (in descending order of frequency): 9p23-p24 (48%), 13q21 (47%), 6q16 (44%), 6q26-q27 (44%), 8p23 (37%), 18q22- q23 (37%), 17p12-p13 (34%), 1p36.1 (34%), 11q23 (33%), 1p22 (32%), 4q32-qter (31%), 14q22q23 (25%), 10q23 (25%), 10q25-qter (25%), 15q21 (23%), 16q22 (23%), 5q21 (23%), 3p12-p14 (22%), 22q12 (22%), Xp21 (21%), Xq21 (21%), and 10p12 (20%). The frequency of losses at chromosomes 7 and 20 was less than 10% in all tumors. The chromosomal regions in which the most frequent losses are found implicate locations of essential tumor suppressor genes and DNA repair genes that may be involved in the pathogenesis of several tumor types.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 683-694 |
| Number of pages | 12 |
| Journal | American Journal of Pathology |
| Volume | 155 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
DNA copy number losses in human neoplasms. / Knuutila, Sakari; Aalto, Yan; Autio, Kirsi; Björkqvist, Anna Maria; El-Rifai, Wael; Hemmer, Samuli; Huhta, Tarja; Kettunen, Eeva; Kiuru-Kuhlefelt, Sonja; Larramendy, Marcelo L.; Lushnikova, Tamara; Monni, Outi; Pere, Heini; Tapper, Johanna; Tarkkanen, Maija; Varis, Asta; Wasenius, Veli Matti; Wolf, Maija; Zhu, Ying.
In: American Journal of Pathology, Vol. 155, No. 3, 01.01.1999, p. 683-694.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - DNA copy number losses in human neoplasms
AU - Knuutila, Sakari
AU - Aalto, Yan
AU - Autio, Kirsi
AU - Björkqvist, Anna Maria
AU - El-Rifai, Wael
AU - Hemmer, Samuli
AU - Huhta, Tarja
AU - Kettunen, Eeva
AU - Kiuru-Kuhlefelt, Sonja
AU - Larramendy, Marcelo L.
AU - Lushnikova, Tamara
AU - Monni, Outi
AU - Pere, Heini
AU - Tapper, Johanna
AU - Tarkkanen, Maija
AU - Varis, Asta
AU - Wasenius, Veli Matti
AU - Wolf, Maija
AU - Zhu, Ying
PY - 1999/1/1
Y1 - 1999/1/1
N2 - This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www.helsinki.fi/~1g1-www/CMG.html. The genes relevant to the lost regions are discussed for each of the chromosomes. The review is supplemented also by a list of known and putative tumor suppressor genes and DNA repair genes (see Table 1, online). Losses are found in all chromosome arms, but they seem to be relatively rare at 1q, 2p, 3q, 5p, 6p, 7p, 7q, 8q, 12p, and 20q. Losses and their minimal common overlapping areas that were present in a great proportion of the 73 tumor entities reported in Table 2 (see online) are (in descending order of frequency): 9p23-p24 (48%), 13q21 (47%), 6q16 (44%), 6q26-q27 (44%), 8p23 (37%), 18q22- q23 (37%), 17p12-p13 (34%), 1p36.1 (34%), 11q23 (33%), 1p22 (32%), 4q32-qter (31%), 14q22q23 (25%), 10q23 (25%), 10q25-qter (25%), 15q21 (23%), 16q22 (23%), 5q21 (23%), 3p12-p14 (22%), 22q12 (22%), Xp21 (21%), Xq21 (21%), and 10p12 (20%). The frequency of losses at chromosomes 7 and 20 was less than 10% in all tumors. The chromosomal regions in which the most frequent losses are found implicate locations of essential tumor suppressor genes and DNA repair genes that may be involved in the pathogenesis of several tumor types.
AB - This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www.helsinki.fi/~1g1-www/CMG.html. The genes relevant to the lost regions are discussed for each of the chromosomes. The review is supplemented also by a list of known and putative tumor suppressor genes and DNA repair genes (see Table 1, online). Losses are found in all chromosome arms, but they seem to be relatively rare at 1q, 2p, 3q, 5p, 6p, 7p, 7q, 8q, 12p, and 20q. Losses and their minimal common overlapping areas that were present in a great proportion of the 73 tumor entities reported in Table 2 (see online) are (in descending order of frequency): 9p23-p24 (48%), 13q21 (47%), 6q16 (44%), 6q26-q27 (44%), 8p23 (37%), 18q22- q23 (37%), 17p12-p13 (34%), 1p36.1 (34%), 11q23 (33%), 1p22 (32%), 4q32-qter (31%), 14q22q23 (25%), 10q23 (25%), 10q25-qter (25%), 15q21 (23%), 16q22 (23%), 5q21 (23%), 3p12-p14 (22%), 22q12 (22%), Xp21 (21%), Xq21 (21%), and 10p12 (20%). The frequency of losses at chromosomes 7 and 20 was less than 10% in all tumors. The chromosomal regions in which the most frequent losses are found implicate locations of essential tumor suppressor genes and DNA repair genes that may be involved in the pathogenesis of several tumor types.
UR - http://www.scopus.com/inward/record.url?scp=0032887168&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032887168&partnerID=8YFLogxK
U2 - 10.1016/S0002-9440(10)65166-8
DO - 10.1016/S0002-9440(10)65166-8
M3 - Review article
C2 - 10487825
AN - SCOPUS:0032887168
VL - 155
SP - 683
EP - 694
JO - American Journal of Pathology
JF - American Journal of Pathology
SN - 0002-9440
IS - 3
ER -