DNA copy number losses in human neoplasms

Sakari Knuutila, Yan Aalto, Kirsi Autio, Anna Maria Björkqvist, Wael El-Rifai, Samuli Hemmer, Tarja Huhta, Eeva Kettunen, Sonja Kiuru-Kuhlefelt, Marcelo L. Larramendy, Tamara Lushnikova, Outi Monni, Heini Pere, Johanna Tapper, Maija Tarkkanen, Asta Varis, Veli Matti Wasenius, Maija Wolf, Ying Zhu

Research output: Contribution to journalReview article

347 Citations (Scopus)

Abstract

This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www.helsinki.fi/~1g1-www/CMG.html. The genes relevant to the lost regions are discussed for each of the chromosomes. The review is supplemented also by a list of known and putative tumor suppressor genes and DNA repair genes (see Table 1, online). Losses are found in all chromosome arms, but they seem to be relatively rare at 1q, 2p, 3q, 5p, 6p, 7p, 7q, 8q, 12p, and 20q. Losses and their minimal common overlapping areas that were present in a great proportion of the 73 tumor entities reported in Table 2 (see online) are (in descending order of frequency): 9p23-p24 (48%), 13q21 (47%), 6q16 (44%), 6q26-q27 (44%), 8p23 (37%), 18q22- q23 (37%), 17p12-p13 (34%), 1p36.1 (34%), 11q23 (33%), 1p22 (32%), 4q32-qter (31%), 14q22q23 (25%), 10q23 (25%), 10q25-qter (25%), 15q21 (23%), 16q22 (23%), 5q21 (23%), 3p12-p14 (22%), 22q12 (22%), Xp21 (21%), Xq21 (21%), and 10p12 (20%). The frequency of losses at chromosomes 7 and 20 was less than 10% in all tumors. The chromosomal regions in which the most frequent losses are found implicate locations of essential tumor suppressor genes and DNA repair genes that may be involved in the pathogenesis of several tumor types.

Original languageEnglish (US)
Pages (from-to)683-694
Number of pages12
JournalAmerican Journal of Pathology
Volume155
Issue number3
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Fingerprint

DNA
Chromosomes
Neoplasms
Tumor Suppressor Genes
DNA Repair
Chromosomes, Human, Pair 20
Genes
Chromosomes, Human, Pair 7
Comparative Genomic Hybridization

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Knuutila, S., Aalto, Y., Autio, K., Björkqvist, A. M., El-Rifai, W., Hemmer, S., ... Zhu, Y. (1999). DNA copy number losses in human neoplasms. American Journal of Pathology, 155(3), 683-694. https://doi.org/10.1016/S0002-9440(10)65166-8

DNA copy number losses in human neoplasms. / Knuutila, Sakari; Aalto, Yan; Autio, Kirsi; Björkqvist, Anna Maria; El-Rifai, Wael; Hemmer, Samuli; Huhta, Tarja; Kettunen, Eeva; Kiuru-Kuhlefelt, Sonja; Larramendy, Marcelo L.; Lushnikova, Tamara; Monni, Outi; Pere, Heini; Tapper, Johanna; Tarkkanen, Maija; Varis, Asta; Wasenius, Veli Matti; Wolf, Maija; Zhu, Ying.

In: American Journal of Pathology, Vol. 155, No. 3, 01.01.1999, p. 683-694.

Research output: Contribution to journalReview article

Knuutila, S, Aalto, Y, Autio, K, Björkqvist, AM, El-Rifai, W, Hemmer, S, Huhta, T, Kettunen, E, Kiuru-Kuhlefelt, S, Larramendy, ML, Lushnikova, T, Monni, O, Pere, H, Tapper, J, Tarkkanen, M, Varis, A, Wasenius, VM, Wolf, M & Zhu, Y 1999, 'DNA copy number losses in human neoplasms', American Journal of Pathology, vol. 155, no. 3, pp. 683-694. https://doi.org/10.1016/S0002-9440(10)65166-8
Knuutila S, Aalto Y, Autio K, Björkqvist AM, El-Rifai W, Hemmer S et al. DNA copy number losses in human neoplasms. American Journal of Pathology. 1999 Jan 1;155(3):683-694. https://doi.org/10.1016/S0002-9440(10)65166-8
Knuutila, Sakari ; Aalto, Yan ; Autio, Kirsi ; Björkqvist, Anna Maria ; El-Rifai, Wael ; Hemmer, Samuli ; Huhta, Tarja ; Kettunen, Eeva ; Kiuru-Kuhlefelt, Sonja ; Larramendy, Marcelo L. ; Lushnikova, Tamara ; Monni, Outi ; Pere, Heini ; Tapper, Johanna ; Tarkkanen, Maija ; Varis, Asta ; Wasenius, Veli Matti ; Wolf, Maija ; Zhu, Ying. / DNA copy number losses in human neoplasms. In: American Journal of Pathology. 1999 ; Vol. 155, No. 3. pp. 683-694.
@article{073fe93fa93d4dddbcb3dc74a94fd2a7,
title = "DNA copy number losses in human neoplasms",
abstract = "This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www.helsinki.fi/~1g1-www/CMG.html. The genes relevant to the lost regions are discussed for each of the chromosomes. The review is supplemented also by a list of known and putative tumor suppressor genes and DNA repair genes (see Table 1, online). Losses are found in all chromosome arms, but they seem to be relatively rare at 1q, 2p, 3q, 5p, 6p, 7p, 7q, 8q, 12p, and 20q. Losses and their minimal common overlapping areas that were present in a great proportion of the 73 tumor entities reported in Table 2 (see online) are (in descending order of frequency): 9p23-p24 (48{\%}), 13q21 (47{\%}), 6q16 (44{\%}), 6q26-q27 (44{\%}), 8p23 (37{\%}), 18q22- q23 (37{\%}), 17p12-p13 (34{\%}), 1p36.1 (34{\%}), 11q23 (33{\%}), 1p22 (32{\%}), 4q32-qter (31{\%}), 14q22q23 (25{\%}), 10q23 (25{\%}), 10q25-qter (25{\%}), 15q21 (23{\%}), 16q22 (23{\%}), 5q21 (23{\%}), 3p12-p14 (22{\%}), 22q12 (22{\%}), Xp21 (21{\%}), Xq21 (21{\%}), and 10p12 (20{\%}). The frequency of losses at chromosomes 7 and 20 was less than 10{\%} in all tumors. The chromosomal regions in which the most frequent losses are found implicate locations of essential tumor suppressor genes and DNA repair genes that may be involved in the pathogenesis of several tumor types.",
author = "Sakari Knuutila and Yan Aalto and Kirsi Autio and Bj{\"o}rkqvist, {Anna Maria} and Wael El-Rifai and Samuli Hemmer and Tarja Huhta and Eeva Kettunen and Sonja Kiuru-Kuhlefelt and Larramendy, {Marcelo L.} and Tamara Lushnikova and Outi Monni and Heini Pere and Johanna Tapper and Maija Tarkkanen and Asta Varis and Wasenius, {Veli Matti} and Maija Wolf and Ying Zhu",
year = "1999",
month = "1",
day = "1",
doi = "10.1016/S0002-9440(10)65166-8",
language = "English (US)",
volume = "155",
pages = "683--694",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - DNA copy number losses in human neoplasms

AU - Knuutila, Sakari

AU - Aalto, Yan

AU - Autio, Kirsi

AU - Björkqvist, Anna Maria

AU - El-Rifai, Wael

AU - Hemmer, Samuli

AU - Huhta, Tarja

AU - Kettunen, Eeva

AU - Kiuru-Kuhlefelt, Sonja

AU - Larramendy, Marcelo L.

AU - Lushnikova, Tamara

AU - Monni, Outi

AU - Pere, Heini

AU - Tapper, Johanna

AU - Tarkkanen, Maija

AU - Varis, Asta

AU - Wasenius, Veli Matti

AU - Wolf, Maija

AU - Zhu, Ying

PY - 1999/1/1

Y1 - 1999/1/1

N2 - This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www.helsinki.fi/~1g1-www/CMG.html. The genes relevant to the lost regions are discussed for each of the chromosomes. The review is supplemented also by a list of known and putative tumor suppressor genes and DNA repair genes (see Table 1, online). Losses are found in all chromosome arms, but they seem to be relatively rare at 1q, 2p, 3q, 5p, 6p, 7p, 7q, 8q, 12p, and 20q. Losses and their minimal common overlapping areas that were present in a great proportion of the 73 tumor entities reported in Table 2 (see online) are (in descending order of frequency): 9p23-p24 (48%), 13q21 (47%), 6q16 (44%), 6q26-q27 (44%), 8p23 (37%), 18q22- q23 (37%), 17p12-p13 (34%), 1p36.1 (34%), 11q23 (33%), 1p22 (32%), 4q32-qter (31%), 14q22q23 (25%), 10q23 (25%), 10q25-qter (25%), 15q21 (23%), 16q22 (23%), 5q21 (23%), 3p12-p14 (22%), 22q12 (22%), Xp21 (21%), Xq21 (21%), and 10p12 (20%). The frequency of losses at chromosomes 7 and 20 was less than 10% in all tumors. The chromosomal regions in which the most frequent losses are found implicate locations of essential tumor suppressor genes and DNA repair genes that may be involved in the pathogenesis of several tumor types.

AB - This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses that affect each of the chromosome arms in 73 tumor types are tabulated from 169 reports. The tables are available online at http://www.amjpathol.org and http://www.helsinki.fi/~1g1-www/CMG.html. The genes relevant to the lost regions are discussed for each of the chromosomes. The review is supplemented also by a list of known and putative tumor suppressor genes and DNA repair genes (see Table 1, online). Losses are found in all chromosome arms, but they seem to be relatively rare at 1q, 2p, 3q, 5p, 6p, 7p, 7q, 8q, 12p, and 20q. Losses and their minimal common overlapping areas that were present in a great proportion of the 73 tumor entities reported in Table 2 (see online) are (in descending order of frequency): 9p23-p24 (48%), 13q21 (47%), 6q16 (44%), 6q26-q27 (44%), 8p23 (37%), 18q22- q23 (37%), 17p12-p13 (34%), 1p36.1 (34%), 11q23 (33%), 1p22 (32%), 4q32-qter (31%), 14q22q23 (25%), 10q23 (25%), 10q25-qter (25%), 15q21 (23%), 16q22 (23%), 5q21 (23%), 3p12-p14 (22%), 22q12 (22%), Xp21 (21%), Xq21 (21%), and 10p12 (20%). The frequency of losses at chromosomes 7 and 20 was less than 10% in all tumors. The chromosomal regions in which the most frequent losses are found implicate locations of essential tumor suppressor genes and DNA repair genes that may be involved in the pathogenesis of several tumor types.

UR - http://www.scopus.com/inward/record.url?scp=0032887168&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032887168&partnerID=8YFLogxK

U2 - 10.1016/S0002-9440(10)65166-8

DO - 10.1016/S0002-9440(10)65166-8

M3 - Review article

C2 - 10487825

AN - SCOPUS:0032887168

VL - 155

SP - 683

EP - 694

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 3

ER -