DNA copy number changes in development and progression in leiomyosarcomas of soft tissues

Wael El-Rifai, Maarit Sarlomo-Rikala, Sakari Knuutila, Markku Miettinen

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

DNA copy number changes were investigated in 29 leiomyosarcomas by comparative genomic hybridization. The most frequent losses were detected in 10q (20 cases, 69%) and 13q (17 cases, 59%). The most frequent gains were detected in 17p (16 cases, 55%). The most frequent high-level amplifications were detected in 17p (7 cases, 24%) and 8q (6 cases, 21%). A total of 137 losses and 204 gains were detected. Small tumors (less than 5 cm in diameter) displayed fewer changes per sample (3 to 11; mean, 7) than the other tumors (4 to 22; mean, 13). There was an increase in the number of gains from small tumors (mean, 4) to very large tumors (>20 cm; mean, 10). However, the number of losses was similar in small, large, and very large tumors (mean, 4.5). Tumor size-related aberrations were observed. Gains in 16p were detected in all small tumors but were infrequent in large and very large tumors (27% and 11%, respectively). Similarly, gains and high-level amplifications in 17p were more common in small (80%) than in very large tumors (33%). Gains in 1q, 5p, 6q, and 8q were not seen in any of the small tumors but were detected in large and very large tumors. Gains in 6q and 8q occurred in 8 of 9 cases (89%) of very large tumors, 5 of them with a high-level amplification in 8q.

Original languageEnglish (US)
Pages (from-to)985-990
Number of pages6
JournalAmerican Journal of Pathology
Volume153
Issue number3
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Fingerprint

DNA Copy Number Variations
Leiomyosarcoma
Neoplasms
Comparative Genomic Hybridization

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

DNA copy number changes in development and progression in leiomyosarcomas of soft tissues. / El-Rifai, Wael; Sarlomo-Rikala, Maarit; Knuutila, Sakari; Miettinen, Markku.

In: American Journal of Pathology, Vol. 153, No. 3, 01.01.1998, p. 985-990.

Research output: Contribution to journalArticle

El-Rifai, Wael ; Sarlomo-Rikala, Maarit ; Knuutila, Sakari ; Miettinen, Markku. / DNA copy number changes in development and progression in leiomyosarcomas of soft tissues. In: American Journal of Pathology. 1998 ; Vol. 153, No. 3. pp. 985-990.
@article{8bf8c16f011c4c75a90634a32cc0f7b0,
title = "DNA copy number changes in development and progression in leiomyosarcomas of soft tissues",
abstract = "DNA copy number changes were investigated in 29 leiomyosarcomas by comparative genomic hybridization. The most frequent losses were detected in 10q (20 cases, 69{\%}) and 13q (17 cases, 59{\%}). The most frequent gains were detected in 17p (16 cases, 55{\%}). The most frequent high-level amplifications were detected in 17p (7 cases, 24{\%}) and 8q (6 cases, 21{\%}). A total of 137 losses and 204 gains were detected. Small tumors (less than 5 cm in diameter) displayed fewer changes per sample (3 to 11; mean, 7) than the other tumors (4 to 22; mean, 13). There was an increase in the number of gains from small tumors (mean, 4) to very large tumors (>20 cm; mean, 10). However, the number of losses was similar in small, large, and very large tumors (mean, 4.5). Tumor size-related aberrations were observed. Gains in 16p were detected in all small tumors but were infrequent in large and very large tumors (27{\%} and 11{\%}, respectively). Similarly, gains and high-level amplifications in 17p were more common in small (80{\%}) than in very large tumors (33{\%}). Gains in 1q, 5p, 6q, and 8q were not seen in any of the small tumors but were detected in large and very large tumors. Gains in 6q and 8q occurred in 8 of 9 cases (89{\%}) of very large tumors, 5 of them with a high-level amplification in 8q.",
author = "Wael El-Rifai and Maarit Sarlomo-Rikala and Sakari Knuutila and Markku Miettinen",
year = "1998",
month = "1",
day = "1",
doi = "10.1016/S0002-9440(10)65640-4",
language = "English (US)",
volume = "153",
pages = "985--990",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - DNA copy number changes in development and progression in leiomyosarcomas of soft tissues

AU - El-Rifai, Wael

AU - Sarlomo-Rikala, Maarit

AU - Knuutila, Sakari

AU - Miettinen, Markku

PY - 1998/1/1

Y1 - 1998/1/1

N2 - DNA copy number changes were investigated in 29 leiomyosarcomas by comparative genomic hybridization. The most frequent losses were detected in 10q (20 cases, 69%) and 13q (17 cases, 59%). The most frequent gains were detected in 17p (16 cases, 55%). The most frequent high-level amplifications were detected in 17p (7 cases, 24%) and 8q (6 cases, 21%). A total of 137 losses and 204 gains were detected. Small tumors (less than 5 cm in diameter) displayed fewer changes per sample (3 to 11; mean, 7) than the other tumors (4 to 22; mean, 13). There was an increase in the number of gains from small tumors (mean, 4) to very large tumors (>20 cm; mean, 10). However, the number of losses was similar in small, large, and very large tumors (mean, 4.5). Tumor size-related aberrations were observed. Gains in 16p were detected in all small tumors but were infrequent in large and very large tumors (27% and 11%, respectively). Similarly, gains and high-level amplifications in 17p were more common in small (80%) than in very large tumors (33%). Gains in 1q, 5p, 6q, and 8q were not seen in any of the small tumors but were detected in large and very large tumors. Gains in 6q and 8q occurred in 8 of 9 cases (89%) of very large tumors, 5 of them with a high-level amplification in 8q.

AB - DNA copy number changes were investigated in 29 leiomyosarcomas by comparative genomic hybridization. The most frequent losses were detected in 10q (20 cases, 69%) and 13q (17 cases, 59%). The most frequent gains were detected in 17p (16 cases, 55%). The most frequent high-level amplifications were detected in 17p (7 cases, 24%) and 8q (6 cases, 21%). A total of 137 losses and 204 gains were detected. Small tumors (less than 5 cm in diameter) displayed fewer changes per sample (3 to 11; mean, 7) than the other tumors (4 to 22; mean, 13). There was an increase in the number of gains from small tumors (mean, 4) to very large tumors (>20 cm; mean, 10). However, the number of losses was similar in small, large, and very large tumors (mean, 4.5). Tumor size-related aberrations were observed. Gains in 16p were detected in all small tumors but were infrequent in large and very large tumors (27% and 11%, respectively). Similarly, gains and high-level amplifications in 17p were more common in small (80%) than in very large tumors (33%). Gains in 1q, 5p, 6q, and 8q were not seen in any of the small tumors but were detected in large and very large tumors. Gains in 6q and 8q occurred in 8 of 9 cases (89%) of very large tumors, 5 of them with a high-level amplification in 8q.

UR - http://www.scopus.com/inward/record.url?scp=0031662263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031662263&partnerID=8YFLogxK

U2 - 10.1016/S0002-9440(10)65640-4

DO - 10.1016/S0002-9440(10)65640-4

M3 - Article

C2 - 9736047

AN - SCOPUS:0031662263

VL - 153

SP - 985

EP - 990

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 3

ER -