DNA copy number amplifications in human neoplasms: Review of comparative genomic hybridization studies

S. Knuutila, A. M. Bjorkqvist, K. Autio, M. Tarkkanen, M. Wolf, O. Monni, J. Szymanska, M. L. Larramendy, J. Tapper, H. Pere, Wael El-Rifai, S. Hemmer, V. M. Wasenius, V. Vidgren, Y. Zhu

Research output: Contribution to journalReview article

499 Citations (Scopus)

Abstract

This review summarizes reports of recurrent DNA sequence copy number amplifications in human neoplasms detected by comparative genomic hybridization. Some of the chromosomal areas with recurrent DNA copy number amplifications (amplicons) of 1p22-p31, 1p32-p36, 1q, 2p13-p16, 2p23-p25, 2q31q33, 3q, 5p, 6p12-pter, 7p12-p13, 7q11.2, 7q21-q22, 8p11-p12, 8q, 11q13- q14, 12p, 12q13-q21, 13q14, 13q22-qter, 14q13-q21, 15q24-qter, 17p11.2-p12, 17q12-q21, 17q22-qter, 18q, 19p13.2-pter, 19cenq13.3, 20p11.2-p12, 20q, Xp11.2-p21, and Xp11-q13 and genes therein are presented in more detail. The paper with more than 150 references and two tables can be accessed from our web site http://www.helsinki.fi/~lgl www/CMG.html. The data will be updated biannually until the year 2001.

Original languageEnglish (US)
Pages (from-to)1107-1123
Number of pages17
JournalAmerican Journal of Pathology
Volume152
Issue number5
StatePublished - May 26 1998
Externally publishedYes

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Comparative Genomic Hybridization
DNA
Genes
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Knuutila, S., Bjorkqvist, A. M., Autio, K., Tarkkanen, M., Wolf, M., Monni, O., ... Zhu, Y. (1998). DNA copy number amplifications in human neoplasms: Review of comparative genomic hybridization studies. American Journal of Pathology, 152(5), 1107-1123.

DNA copy number amplifications in human neoplasms : Review of comparative genomic hybridization studies. / Knuutila, S.; Bjorkqvist, A. M.; Autio, K.; Tarkkanen, M.; Wolf, M.; Monni, O.; Szymanska, J.; Larramendy, M. L.; Tapper, J.; Pere, H.; El-Rifai, Wael; Hemmer, S.; Wasenius, V. M.; Vidgren, V.; Zhu, Y.

In: American Journal of Pathology, Vol. 152, No. 5, 26.05.1998, p. 1107-1123.

Research output: Contribution to journalReview article

Knuutila, S, Bjorkqvist, AM, Autio, K, Tarkkanen, M, Wolf, M, Monni, O, Szymanska, J, Larramendy, ML, Tapper, J, Pere, H, El-Rifai, W, Hemmer, S, Wasenius, VM, Vidgren, V & Zhu, Y 1998, 'DNA copy number amplifications in human neoplasms: Review of comparative genomic hybridization studies', American Journal of Pathology, vol. 152, no. 5, pp. 1107-1123.
Knuutila S, Bjorkqvist AM, Autio K, Tarkkanen M, Wolf M, Monni O et al. DNA copy number amplifications in human neoplasms: Review of comparative genomic hybridization studies. American Journal of Pathology. 1998 May 26;152(5):1107-1123.
Knuutila, S. ; Bjorkqvist, A. M. ; Autio, K. ; Tarkkanen, M. ; Wolf, M. ; Monni, O. ; Szymanska, J. ; Larramendy, M. L. ; Tapper, J. ; Pere, H. ; El-Rifai, Wael ; Hemmer, S. ; Wasenius, V. M. ; Vidgren, V. ; Zhu, Y. / DNA copy number amplifications in human neoplasms : Review of comparative genomic hybridization studies. In: American Journal of Pathology. 1998 ; Vol. 152, No. 5. pp. 1107-1123.
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