DNA copy number amplifications in human neoplasms: Review of comparative genomic hybridization studies

S. Knuutila, A. M. Bjorkqvist, K. Autio, M. Tarkkanen, M. Wolf, O. Monni, J. Szymanska, M. L. Larramendy, J. Tapper, H. Pere, W. El-Rifai, S. Hemmer, V. M. Wasenius, V. Vidgren, Y. Zhu

Research output: Contribution to journalReview article

502 Scopus citations

Abstract

This review summarizes reports of recurrent DNA sequence copy number amplifications in human neoplasms detected by comparative genomic hybridization. Some of the chromosomal areas with recurrent DNA copy number amplifications (amplicons) of 1p22-p31, 1p32-p36, 1q, 2p13-p16, 2p23-p25, 2q31q33, 3q, 5p, 6p12-pter, 7p12-p13, 7q11.2, 7q21-q22, 8p11-p12, 8q, 11q13- q14, 12p, 12q13-q21, 13q14, 13q22-qter, 14q13-q21, 15q24-qter, 17p11.2-p12, 17q12-q21, 17q22-qter, 18q, 19p13.2-pter, 19cenq13.3, 20p11.2-p12, 20q, Xp11.2-p21, and Xp11-q13 and genes therein are presented in more detail. The paper with more than 150 references and two tables can be accessed from our web site http://www.helsinki.fi/~lgl www/CMG.html. The data will be updated biannually until the year 2001.

Original languageEnglish (US)
Pages (from-to)1107-1123
Number of pages17
JournalAmerican Journal of Pathology
Volume152
Issue number5
StatePublished - May 26 1998
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'DNA copy number amplifications in human neoplasms: Review of comparative genomic hybridization studies'. Together they form a unique fingerprint.

  • Cite this

    Knuutila, S., Bjorkqvist, A. M., Autio, K., Tarkkanen, M., Wolf, M., Monni, O., Szymanska, J., Larramendy, M. L., Tapper, J., Pere, H., El-Rifai, W., Hemmer, S., Wasenius, V. M., Vidgren, V., & Zhu, Y. (1998). DNA copy number amplifications in human neoplasms: Review of comparative genomic hybridization studies. American Journal of Pathology, 152(5), 1107-1123.