Abstract
The protein encoded by the human testis determining gene, SRY, contains a high mobility group (HMG) box related to that present in the T cell-specific, DNA-binding protein TCF-1. Recombinant SRY protein was able to bind to the same core sequence ACAAAG recognized by TCF-1 in a sequence dependent manner. In five XY females point mutations were found in the region encoding the HMG box. In four cases DNA binding activity of mutant SRY protein was negligible; in the fifth case DNA binding was reduced. These results imply that the DNA binding activity of SRY is required for sex determination.
Original language | English (US) |
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Pages (from-to) | 453-456 |
Number of pages | 4 |
Journal | Science |
Volume | 255 |
Issue number | 5043 |
DOIs | |
State | Published - Jan 1 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- General