Diverse regulatory interactions of long noncoding RNAs

Tae Kyung Kim, Ramin Shiekhattar

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Studies in the past decade indicate that a large number of lncRNAs are enriched in the nucleus and originate from transcriptionally active regulatory elements. These lncRNAs associate with transcription factors and chromatin regulatory elements to fine-tune the transcriptional output of protein coding genes. Importantly, lncRNAs display exquisite tissue specificity in their expression. Understanding how lncRNAs associate with their protein or nucleic acid partners and how they modulate gene expression provides insight into their scope of biological function. This review discusses notable functional properties and mechanisms of action of lncRNAs that have resulted from recent progress made in the field.

Original languageEnglish (US)
Pages (from-to)73-82
Number of pages10
JournalCurrent Opinion in Genetics and Development
Volume36
DOIs
StatePublished - Feb 1 2016

Fingerprint

Long Noncoding RNA
Organ Specificity
Nucleic Acids
Chromatin
Proteins
Transcription Factors
Gene Expression

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Diverse regulatory interactions of long noncoding RNAs. / Kim, Tae Kyung; Shiekhattar, Ramin.

In: Current Opinion in Genetics and Development, Vol. 36, 01.02.2016, p. 73-82.

Research output: Contribution to journalArticle

@article{afdca0eb350944649a524ee6ea71b5ff,
title = "Diverse regulatory interactions of long noncoding RNAs",
abstract = "Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Studies in the past decade indicate that a large number of lncRNAs are enriched in the nucleus and originate from transcriptionally active regulatory elements. These lncRNAs associate with transcription factors and chromatin regulatory elements to fine-tune the transcriptional output of protein coding genes. Importantly, lncRNAs display exquisite tissue specificity in their expression. Understanding how lncRNAs associate with their protein or nucleic acid partners and how they modulate gene expression provides insight into their scope of biological function. This review discusses notable functional properties and mechanisms of action of lncRNAs that have resulted from recent progress made in the field.",
author = "Kim, {Tae Kyung} and Ramin Shiekhattar",
year = "2016",
month = "2",
day = "1",
doi = "10.1016/j.gde.2016.03.014",
language = "English (US)",
volume = "36",
pages = "73--82",
journal = "Current Opinion in Genetics and Development",
issn = "0959-437X",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Diverse regulatory interactions of long noncoding RNAs

AU - Kim, Tae Kyung

AU - Shiekhattar, Ramin

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Studies in the past decade indicate that a large number of lncRNAs are enriched in the nucleus and originate from transcriptionally active regulatory elements. These lncRNAs associate with transcription factors and chromatin regulatory elements to fine-tune the transcriptional output of protein coding genes. Importantly, lncRNAs display exquisite tissue specificity in their expression. Understanding how lncRNAs associate with their protein or nucleic acid partners and how they modulate gene expression provides insight into their scope of biological function. This review discusses notable functional properties and mechanisms of action of lncRNAs that have resulted from recent progress made in the field.

AB - Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Studies in the past decade indicate that a large number of lncRNAs are enriched in the nucleus and originate from transcriptionally active regulatory elements. These lncRNAs associate with transcription factors and chromatin regulatory elements to fine-tune the transcriptional output of protein coding genes. Importantly, lncRNAs display exquisite tissue specificity in their expression. Understanding how lncRNAs associate with their protein or nucleic acid partners and how they modulate gene expression provides insight into their scope of biological function. This review discusses notable functional properties and mechanisms of action of lncRNAs that have resulted from recent progress made in the field.

UR - http://www.scopus.com/inward/record.url?scp=84966264061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966264061&partnerID=8YFLogxK

U2 - 10.1016/j.gde.2016.03.014

DO - 10.1016/j.gde.2016.03.014

M3 - Article

VL - 36

SP - 73

EP - 82

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

SN - 0959-437X

ER -