Abstract
Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.
| Original language | English |
|---|---|
| Pages (from-to) | 164-179 |
| Number of pages | 16 |
| Journal | Marine Drugs |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2008 |
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Keywords
- Biosynthesis
- Okadaic acid
- Polyketide
- Polyketide synthase
- Roseobacter
ASJC Scopus subject areas
- Drug Discovery
- Molecular Medicine
- Aquatic Science
Cite this
Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates. / Perez, Roberto; Liu, Li; Lopez, Jose; An, Tianying; Rein, Kathleen S.
In: Marine Drugs, Vol. 6, No. 2, 01.06.2008, p. 164-179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates
AU - Perez, Roberto
AU - Liu, Li
AU - Lopez, Jose
AU - An, Tianying
AU - Rein, Kathleen S.
PY - 2008/6/1
Y1 - 2008/6/1
N2 - Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.
AB - Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.
KW - Biosynthesis
KW - Okadaic acid
KW - Polyketide
KW - Polyketide synthase
KW - Roseobacter
UR - http://www.scopus.com/inward/record.url?scp=46349097041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=46349097041&partnerID=8YFLogxK
U2 - 10.3390/md20080009
DO - 10.3390/md20080009
M3 - Article
C2 - 18728765
AN - SCOPUS:46349097041
VL - 6
SP - 164
EP - 179
JO - Marine Drugs
JF - Marine Drugs
SN - 1660-3397
IS - 2
ER -