Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates

Roberto Perez; Li Liu; Jose Lopez; Tianying An; Kathleen S. Rein

doi:10.3390/md6020164

Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates

Roberto Perez, Li Liu, Jose Lopez, Tianying An, Kathleen S. Rein

Pathology

Research output: Contribution to journal › Article

14 Scopus citations

Abstract

Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.

Original language	English (US)
Pages (from-to)	164-179
Number of pages	16
Journal	Marine Drugs
Volume	6
Issue number	2
DOIs	https://doi.org/10.3390/md6020164
State	Published - Jun 2008

Keywords

Biosynthesis
Okadaic acid
Polyketide
Polyketide synthase
Roseobacter

ASJC Scopus subject areas

Drug Discovery
Molecular Medicine
Aquatic Science

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10.3390/md6020164

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Perez, R., Liu, L., Lopez, J., An, T., & Rein, K. S. (2008). Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates. Marine Drugs, 6(2), 164-179. https://doi.org/10.3390/md6020164

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