Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates

Roberto Perez, Li Liu, Jose Lopez, Tianying An, Kathleen S. Rein

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.

Original languageEnglish (US)
Pages (from-to)164-179
Number of pages16
JournalMarine Drugs
Volume6
Issue number2
DOIs
StatePublished - Jun 2008

Keywords

  • Biosynthesis
  • Okadaic acid
  • Polyketide
  • Polyketide synthase
  • Roseobacter

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Aquatic Science

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