Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates

Roberto Perez, Li Liu, Jose Lopez, Tianying An, Kathleen S. Rein

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.

Original languageEnglish
Pages (from-to)164-179
Number of pages16
JournalMarine Drugs
Volume6
Issue number2
DOIs
StatePublished - Jun 1 2008

Fingerprint

Polyketide Synthases
polyketide synthases
Dinoflagellida
okadaic acid
Okadaic Acid
Roseobacter
dinoflagellate
Prorocentrum
acid
dinophysistoxins
Rhodobacteraceae
Dinophysis
Bacteria
bacterium
bacteria
Libraries
ribosomal RNA
Miozoa
gene
Genes

Keywords

  • Biosynthesis
  • Okadaic acid
  • Polyketide
  • Polyketide synthase
  • Roseobacter

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Aquatic Science

Cite this

Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates. / Perez, Roberto; Liu, Li; Lopez, Jose; An, Tianying; Rein, Kathleen S.

In: Marine Drugs, Vol. 6, No. 2, 01.06.2008, p. 164-179.

Research output: Contribution to journalArticle

Perez, Roberto ; Liu, Li ; Lopez, Jose ; An, Tianying ; Rein, Kathleen S. / Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates. In: Marine Drugs. 2008 ; Vol. 6, No. 2. pp. 164-179.
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