Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells

Gabriela M. Wiedemann, Simon Grassmann, Colleen M. Lau, Moritz Rapp, Alejandro V. Villarino, Christin Friedrich, Georg Gasteiger, John J. O'Shea, Joseph C. Sun

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Wiedemann et al. demonstrate that Stat5a and Stat5b are induced by IL-12 and STAT4 signaling in NK cells following MCMV infection. They further provide evidence that the cytokines IL-2 and IL-15 upstream of STAT5 differentially promote the early and late stages of the adaptive NK cell response to MCMV infection.

Original languageEnglish (US)
Article number108498
JournalCell Reports
Volume33
Issue number11
DOIs
StatePublished - Dec 15 2020
Externally publishedYes

Keywords

  • clonal expansion
  • IL-15
  • IL-2
  • MCMV
  • memory
  • NK cell
  • STAT5

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells'. Together they form a unique fingerprint.

Cite this