Divergent appearance of complement receptors and Fc receptors on T cells in a murine mammary tumor system

Robert S. Epstein, Diana M. Lopez, M. Michael Sigel

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Abstract

The emergence of novel T cells during mammary tumorigenesis has been previously described. T cells with surface markers usually associated with B cells, i.e. complement receptors (CR), appear in the spleens from tumor bearing mice. We now report on the appearance of Fc receptor (FcR) positive T cells in the spleens from the same animals. The kinetics of appearance of the two kinds of cells are similar. Based on evidence from double and triple label assays, it was concluded that FcR and CR are not coexpressed on the same T cell and that the two kinds of T cells which emerge do so in an independent fashion. Furthermore, they appear to represent a branch in the differentiation process influenced by tumor growth. The development of CR+ T cells represents an irreversible process as evidenced by the lack of change in the cells' representation following surgical procedures. In contrast the development of FcR+ T cells appears to be quite flexible in nature since mere surgical trauma as well as tumor mass removal can effect a decrease in the proportion of such cells.

Original languageEnglish (US)
Pages (from-to)154-163
Number of pages10
JournalCellular Immunology
Volume40
Issue number1
DOIs
StatePublished - Sep 15 1978

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ASJC Scopus subject areas

  • Immunology

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