Divergen properties of two human lymphocytic cell lines isolated from a single specimen of peripheral blood

Herbert Lazarus, E. F. Barell, S. Oppenheim, Awtar Krishan

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45 Scopus citations

Abstract

Two lymphocytic cell lines were obtained from a single specimen of peripheral blood buffy coat from a patient with acute lymphoblastic leukemia who concurrently developed classical infectious mononucleosis. These two cell lines exhibit distinguishing differences in culture in parallel with reviously described differences in the cells when implanted into eonatal Syrian hamsters. These observations suggest that the cell lines were derived from two pre-existing different classes or "stelines" of cells-one of which resembles other cell lines derived from patients with acute lymphoblastic leukemia, whereas the other resembles cell lines derived from other, patients with infecttious mononucleosis.

Original languageEnglish
Pages (from-to)303-310
Number of pages8
JournalIn Vitro
Volume9
Issue number5
DOIs
StatePublished - Mar 1 1974
Externally publishedYes

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ASJC Scopus subject areas

  • Developmental Biology
  • Clinical Biochemistry
  • Cell Biology

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