TY - JOUR
T1 - Distribution of ventilation in normal children
AU - Michaelson, E. D.
AU - Wanner, A.
AU - Watson, H.
AU - Silva, G.
AU - Zapata, A.
AU - Serafini-Michaelson, M.
AU - Sackner, M. A.
N1 - Funding Information:
Supported in part by a grant from the American Lung Association.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1979
Y1 - 1979
N2 - Measurements of closing volume and the distribution of ventilation by both single-breath (SBN 2) and multiple-breath nitrogen washout methods were obtained in 376 healthy boys and girls, ages 6 to 18 yr. A closing volume could be demonstrated in 39% of the subjects, and closing volume expressed as percentage of vital capacity did not change with height. Closing capacity expressed as percentage of total lung capacity showed a slight decrease with height. The slope of phase III of the SBN 2 curve decreased with height. Single compartment N 2 washout curves were observed in 72% of the subjects, and the incidence of single compartment curves increased with age. In those subjects with two compartment N 2 washout curves, the relative compartmental ventilation became more even with increasing height. Our observations suggest that parallel units among peripheral airways grow at different rates.
AB - Measurements of closing volume and the distribution of ventilation by both single-breath (SBN 2) and multiple-breath nitrogen washout methods were obtained in 376 healthy boys and girls, ages 6 to 18 yr. A closing volume could be demonstrated in 39% of the subjects, and closing volume expressed as percentage of vital capacity did not change with height. Closing capacity expressed as percentage of total lung capacity showed a slight decrease with height. The slope of phase III of the SBN 2 curve decreased with height. Single compartment N 2 washout curves were observed in 72% of the subjects, and the incidence of single compartment curves increased with age. In those subjects with two compartment N 2 washout curves, the relative compartmental ventilation became more even with increasing height. Our observations suggest that parallel units among peripheral airways grow at different rates.
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U2 - 10.1378/chest.76.6.658
DO - 10.1378/chest.76.6.658
M3 - Article
C2 - 510003
AN - SCOPUS:0018698454
VL - 76
SP - 658
EP - 662
JO - Diseases of the chest
JF - Diseases of the chest
SN - 0012-3692
IS - 6
ER -