Distribution of ventilation in normal children

E. D. Michaelson, A. Wanner, H. Watson, G. Silva, A. Zapata, M. Serafini-Michaelson, M. A. Sackner

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Measurements of closing volume and the distribution of ventilation by both single-breath (SBN 2) and multiple-breath nitrogen washout methods were obtained in 376 healthy boys and girls, ages 6 to 18 yr. A closing volume could be demonstrated in 39% of the subjects, and closing volume expressed as percentage of vital capacity did not change with height. Closing capacity expressed as percentage of total lung capacity showed a slight decrease with height. The slope of phase III of the SBN 2 curve decreased with height. Single compartment N 2 washout curves were observed in 72% of the subjects, and the incidence of single compartment curves increased with age. In those subjects with two compartment N 2 washout curves, the relative compartmental ventilation became more even with increasing height. Our observations suggest that parallel units among peripheral airways grow at different rates.

Original languageEnglish (US)
Pages (from-to)658-662
Number of pages5
Issue number6
StatePublished - 1979

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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