Distribution of the AT1 and AT2 receptors in the rat eye

Y. Zhang, W. Hauswirth, L. Shen, J. Guy, M. I. Phillips

Research output: Contribution to journalArticle

Abstract

Angiotensin II (Ang II) receptors are widely distributed in the body. Both AT1 and AT2 subtypes of receptors can be identified by the use of losartan, an AT1 antagonist, or PD123319, an AT2 antagonist. In this study we found that both receptors are also distributed in the eye. Eyes from Sprague Dawley rats (n=4) were frozen and sectioned for autoradiography. Slices of whole eye were treated with either losartan (1 μM) or with PD123.319 (1 μM). The autoradiographs were imaged and alternate sections were stained with toluidine blue. The results showed that AT1 and AT2 receptors are distributed in the choroid and in the photo receptors of the retina. AT1 but not AT2 were highly expressed in the iris-ciliary body. No Ang II receptors were found in the cornea. The order of AT1 binding was iris-ciliary > choroid > photo receptors. AT2 binding was in choroid > photo receptor. These results suggest that in addition to regulating ocular pressure and vasotone in the eye, Ang II may play a yet unknown role in the activity of the photo receptor cells.

Original languageEnglish (US)
Pages (from-to)A680
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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    Zhang, Y., Hauswirth, W., Shen, L., Guy, J., & Phillips, M. I. (1998). Distribution of the AT1 and AT2 receptors in the rat eye. FASEB Journal, 12(5), A680.