Distribution of 3H-α-MSH in rat brain

Abba J. Kastin, Cheryl Nissen, Karoly Nikolics, Kalmen Medzihradszky, David H. Coy, Istvan Teplan, Andrew V. Schally

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92 Scopus citations


Radioactive synthetic α-MSH, prepared by selective tritiation of its dibromo-L-tyrosine2-derivative, was injected into the carotid artery of intact, hypophysectomized or pinealectomized rats. More radioactivity was found in the occipital cortex, cerebellum, and pons-medulla than in most other brain parts of rats decapitated 15 sec and, to a less significant extent, 30 min after injection. Part of this radioactivity behaved like α-MSH in several identification procedures. After administration of 3H-tyrosine, the least radioactivity was consistently found in the pons-medulla. Large amounts of radioactivity after 3H-α-MSH were found in the pituitary and, particularly in the hypophysectomized rats, in the pineal. The half-time disappearance of the first component of radioactivity from the blood of each group of rats injected with tritiated-α-MSH was no more than 2.5 minutes, a time considerably shorter than the behavioral and EEG effects of this pituitary hormone on visual attention.

Original languageEnglish (US)
Pages (from-to)19-26
Number of pages8
JournalBrain Research Bulletin
Issue number1
StatePublished - 1976
Externally publishedYes


  • Brain
  • Hypothalamus
  • MSH
  • Pineal
  • Pituitary

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)


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