Distribution of Semen Parameters Among Adolescent Males Undergoing Fertility Preservation in a Multicenter International Cohort

Joshua A. Halpern, Nannan Thirumavalavan, Taylor P. Kohn, Amir S. Patel, Joon Yau Leong, Raimondo M. Cervellione, David J.B. Keene, Emad Ibrahim, Nancy Brackett, Dolores J. Lamb, Ranjith Ramasamy

Research output: Contribution to journalArticle

Abstract

Objective: To determine the distribution of semen parameters among adolescent and adult males presenting for fertility preservation. Methods: A retrospective, cross-sectional cohort study of adolescent males age 11-19 who underwent semen analysis for fertility preservation at 3 centers in 2 countries with a comparison cohort of adult men presenting for fertility preservation. Prevalence of azoospermia and distribution of semen parameters was compared across groups. Results: A total of 197 adolescents and 95 adults underwent semen analysis for fertility preservation. Azoospermia was present in 17 (8.6%) adolescents and 3 (3.2%) adults. There was decline in the prevalence of azoospermia with increasing age. After exclusion of patients with azoospermia, the adolescent and adult cohorts were comprised of 180 and 92 patients, respectively. Median age at presentation among adolescents vs adults was 16.5 years (interquartile range [IQR] 15.2-17.6) and 30.8 years (IQR 22.7-43.8), respectively. Median semen volume was 1.0mL (IQR 0.5-2.0) vs 2.5mL (IQR 1.5-3.5), P <.001. Median sperm concentration was 30 million/mL (IQR 10-57) vs 39 million/mL (IQR 14-57), P =.2. Median sperm motility was 39% (IQR 20-55) vs 45% (IQR 35-55), P =.01. Median total motile sperm count was 11 million (IQR 1.4-33) for adolescents vs 29 million (IQR 13-69) for adults, P <.001. Conclusion: Young adolescent males had higher prevalence of azoospermia and lower semen parameters compared to adults. In conjunction with physical examination, Tanner stage, and specific clinical context, these data can help to inform patients and their families about potential for fertility preservation, even in very young adolescent patients.

Original languageEnglish (US)
JournalUrology
DOIs
StatePublished - Jan 1 2019

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Fertility Preservation
Semen
Azoospermia
Semen Analysis
Sperm Count
Sperm Motility
Physical Examination
Spermatozoa
Cohort Studies
Cross-Sectional Studies

ASJC Scopus subject areas

  • Urology

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Distribution of Semen Parameters Among Adolescent Males Undergoing Fertility Preservation in a Multicenter International Cohort. / Halpern, Joshua A.; Thirumavalavan, Nannan; Kohn, Taylor P.; Patel, Amir S.; Leong, Joon Yau; Cervellione, Raimondo M.; Keene, David J.B.; Ibrahim, Emad; Brackett, Nancy; Lamb, Dolores J.; Ramasamy, Ranjith.

In: Urology, 01.01.2019.

Research output: Contribution to journalArticle

Halpern, Joshua A. ; Thirumavalavan, Nannan ; Kohn, Taylor P. ; Patel, Amir S. ; Leong, Joon Yau ; Cervellione, Raimondo M. ; Keene, David J.B. ; Ibrahim, Emad ; Brackett, Nancy ; Lamb, Dolores J. ; Ramasamy, Ranjith. / Distribution of Semen Parameters Among Adolescent Males Undergoing Fertility Preservation in a Multicenter International Cohort. In: Urology. 2019.
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abstract = "Objective: To determine the distribution of semen parameters among adolescent and adult males presenting for fertility preservation. Methods: A retrospective, cross-sectional cohort study of adolescent males age 11-19 who underwent semen analysis for fertility preservation at 3 centers in 2 countries with a comparison cohort of adult men presenting for fertility preservation. Prevalence of azoospermia and distribution of semen parameters was compared across groups. Results: A total of 197 adolescents and 95 adults underwent semen analysis for fertility preservation. Azoospermia was present in 17 (8.6{\%}) adolescents and 3 (3.2{\%}) adults. There was decline in the prevalence of azoospermia with increasing age. After exclusion of patients with azoospermia, the adolescent and adult cohorts were comprised of 180 and 92 patients, respectively. Median age at presentation among adolescents vs adults was 16.5 years (interquartile range [IQR] 15.2-17.6) and 30.8 years (IQR 22.7-43.8), respectively. Median semen volume was 1.0mL (IQR 0.5-2.0) vs 2.5mL (IQR 1.5-3.5), P <.001. Median sperm concentration was 30 million/mL (IQR 10-57) vs 39 million/mL (IQR 14-57), P =.2. Median sperm motility was 39{\%} (IQR 20-55) vs 45{\%} (IQR 35-55), P =.01. Median total motile sperm count was 11 million (IQR 1.4-33) for adolescents vs 29 million (IQR 13-69) for adults, P <.001. Conclusion: Young adolescent males had higher prevalence of azoospermia and lower semen parameters compared to adults. In conjunction with physical examination, Tanner stage, and specific clinical context, these data can help to inform patients and their families about potential for fertility preservation, even in very young adolescent patients.",
author = "Halpern, {Joshua A.} and Nannan Thirumavalavan and Kohn, {Taylor P.} and Patel, {Amir S.} and Leong, {Joon Yau} and Cervellione, {Raimondo M.} and Keene, {David J.B.} and Emad Ibrahim and Nancy Brackett and Lamb, {Dolores J.} and Ranjith Ramasamy",
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T1 - Distribution of Semen Parameters Among Adolescent Males Undergoing Fertility Preservation in a Multicenter International Cohort

AU - Halpern, Joshua A.

AU - Thirumavalavan, Nannan

AU - Kohn, Taylor P.

AU - Patel, Amir S.

AU - Leong, Joon Yau

AU - Cervellione, Raimondo M.

AU - Keene, David J.B.

AU - Ibrahim, Emad

AU - Brackett, Nancy

AU - Lamb, Dolores J.

AU - Ramasamy, Ranjith

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: To determine the distribution of semen parameters among adolescent and adult males presenting for fertility preservation. Methods: A retrospective, cross-sectional cohort study of adolescent males age 11-19 who underwent semen analysis for fertility preservation at 3 centers in 2 countries with a comparison cohort of adult men presenting for fertility preservation. Prevalence of azoospermia and distribution of semen parameters was compared across groups. Results: A total of 197 adolescents and 95 adults underwent semen analysis for fertility preservation. Azoospermia was present in 17 (8.6%) adolescents and 3 (3.2%) adults. There was decline in the prevalence of azoospermia with increasing age. After exclusion of patients with azoospermia, the adolescent and adult cohorts were comprised of 180 and 92 patients, respectively. Median age at presentation among adolescents vs adults was 16.5 years (interquartile range [IQR] 15.2-17.6) and 30.8 years (IQR 22.7-43.8), respectively. Median semen volume was 1.0mL (IQR 0.5-2.0) vs 2.5mL (IQR 1.5-3.5), P <.001. Median sperm concentration was 30 million/mL (IQR 10-57) vs 39 million/mL (IQR 14-57), P =.2. Median sperm motility was 39% (IQR 20-55) vs 45% (IQR 35-55), P =.01. Median total motile sperm count was 11 million (IQR 1.4-33) for adolescents vs 29 million (IQR 13-69) for adults, P <.001. Conclusion: Young adolescent males had higher prevalence of azoospermia and lower semen parameters compared to adults. In conjunction with physical examination, Tanner stage, and specific clinical context, these data can help to inform patients and their families about potential for fertility preservation, even in very young adolescent patients.

AB - Objective: To determine the distribution of semen parameters among adolescent and adult males presenting for fertility preservation. Methods: A retrospective, cross-sectional cohort study of adolescent males age 11-19 who underwent semen analysis for fertility preservation at 3 centers in 2 countries with a comparison cohort of adult men presenting for fertility preservation. Prevalence of azoospermia and distribution of semen parameters was compared across groups. Results: A total of 197 adolescents and 95 adults underwent semen analysis for fertility preservation. Azoospermia was present in 17 (8.6%) adolescents and 3 (3.2%) adults. There was decline in the prevalence of azoospermia with increasing age. After exclusion of patients with azoospermia, the adolescent and adult cohorts were comprised of 180 and 92 patients, respectively. Median age at presentation among adolescents vs adults was 16.5 years (interquartile range [IQR] 15.2-17.6) and 30.8 years (IQR 22.7-43.8), respectively. Median semen volume was 1.0mL (IQR 0.5-2.0) vs 2.5mL (IQR 1.5-3.5), P <.001. Median sperm concentration was 30 million/mL (IQR 10-57) vs 39 million/mL (IQR 14-57), P =.2. Median sperm motility was 39% (IQR 20-55) vs 45% (IQR 35-55), P =.01. Median total motile sperm count was 11 million (IQR 1.4-33) for adolescents vs 29 million (IQR 13-69) for adults, P <.001. Conclusion: Young adolescent males had higher prevalence of azoospermia and lower semen parameters compared to adults. In conjunction with physical examination, Tanner stage, and specific clinical context, these data can help to inform patients and their families about potential for fertility preservation, even in very young adolescent patients.

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