Distribution of radioactivity in the organs of the rat and mouse after injection of [125I]α melanocyte stimulating hormone

A. Dupont, A. J. Kastin, F. Labrie, G. Pelletier, R. Puviani, A. V. Schally

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The distribution of radioactivity after intrajugular injection of 125I labelled α melanocyte stimulating hormone (α MSH) was studied by whole body autoradiography of the mouse and by direct measurement of radioactivity in individual organs of the rat. Very high uptake of radioactivity in the pineal gland was measured 5 min after the injection of [ 125I]α MSH. Lower levels of accumulation of radioactivity were found in the kidney and in the posterior (including intermediate) lobe of the pituitary. High uptake was also found in the thyroid, stomach, and oesophagus. The specificity of uptake of [ 125]α MSH into the pineal and pituitary is suggested by the very low uptake of Na 125I into those tissues.

Original languageEnglish (US)
Pages (from-to)237-241
Number of pages5
JournalUnknown Journal
Volume64
Issue number2
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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