Distribution of radioactivity in the organs of the rat and mouse after injection of [ 125I]α melanocyte stimulating hormone

A. Dupont, A. J. Kastin, F. Labrie, G. Pelletier, R. Puviani, Andrew V Schally

Research output: Contribution to journalArticle

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Abstract

The distribution of radioactivity after intrajugular injection of 125I labelled α melanocyte stimulating hormone (α MSH) was studied by whole body autoradiography of the mouse and by direct measurement of radioactivity in individual organs of the rat. Very high uptake of radioactivity in the pineal gland was measured 5 min after the injection of [ 125I]α MSH. Lower levels of accumulation of radioactivity were found in the kidney and in the posterior (including intermediate) lobe of the pituitary. High uptake was also found in the thyroid, stomach, and oesophagus. The specificity of uptake of [ 125]α MSH into the pineal and pituitary is suggested by the very low uptake of Na 125I into those tissues.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalJournal of Endocrinology
Volume64
Issue number2
StatePublished - Jan 1 1975
Externally publishedYes

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Melanocyte-Stimulating Hormones
Radioactivity
Injections
Intermediate Pituitary Gland
Pineal Gland
Autoradiography
Esophagus
Stomach
Thyroid Gland
Kidney

ASJC Scopus subject areas

  • Endocrinology

Cite this

Distribution of radioactivity in the organs of the rat and mouse after injection of [ 125I]α melanocyte stimulating hormone. / Dupont, A.; Kastin, A. J.; Labrie, F.; Pelletier, G.; Puviani, R.; Schally, Andrew V.

In: Journal of Endocrinology, Vol. 64, No. 2, 01.01.1975, p. 237-241.

Research output: Contribution to journalArticle

Dupont, A. ; Kastin, A. J. ; Labrie, F. ; Pelletier, G. ; Puviani, R. ; Schally, Andrew V. / Distribution of radioactivity in the organs of the rat and mouse after injection of [ 125I]α melanocyte stimulating hormone. In: Journal of Endocrinology. 1975 ; Vol. 64, No. 2. pp. 237-241.
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