Distribution of covalently bound and non covalently bound secretory component on subclasses of rabbit secretory IgA

K. L. Knight, M. L. Vetter, T. R. Malek

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The distribution of non covalently bound secretory component (SC) on the two subclasses, IgA f and IgA g of rabbit secretory IgA (sIgA) was determined; the two subclasses were separated from each other by the use of antibody immunosorbent columns and were subjected to SDS polyacrylamide gel electrophoresis. No SC appeared to be dissociated from the IgA f molecules from each of 11 different rabbits; the IgA g molecules, however, did have SC which was dissociated by SDS. Thus, all of the noncovalently bound SC on rabbit sIgA resides on the IgA g subclass molecules.

Original languageEnglish (US)
Pages (from-to)595-598
Number of pages4
JournalJournal of Immunology
Issue number2
StatePublished - Dec 1 1975


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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