Distribution, frequency, and quantitative analysis of estrogen, progesterone, androgen, and glucocorticoid receptors in human breast cancer

J. C. Allegra, Marc E Lippman, E. B. Thompson, R. Simon, A. Barlock, L. Green, K. K. Huff, H. M. Do, S. C. Aitken

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

The distribution and frequency of steroid hormone receptors are described in 329 patients with breast cancer. The distribution of each of the steroid hormone receptors is unimodal with a progressive increase in the proportion of patients positive at lower receptor values. Receptor values expressed as fmol/mg cytoplasmic protein are well correlated with values expressed as fmol/mg breast tumor. Estrogen receptor was positive in 53% of the patients; progesterone receptor was positive in 38% of the patients; glucocorticoid receptor was positive in 52% of the patients; and androgen receptor was positive in 31% of the patients. The type of tissue assayed did not affect steroid hormone receptor positivity. For primary tumors, there was no correlation between steroid hormone receptor positivity and lcoation of the tumor in the breast, size of the tumor, or extent of the disease. Each of the steroid hormone receptors was positively associated with each of the other steroid homone receptors. Estrogen receptor was correlated with menopausal status and axillary nodal status, but these correlations did not exist for the other steroid hormone receptors. Estrogen receptor was not correlated with age after adjustment for menopausal status. The other steroid hormone receptors were not correlated with age.

Original languageEnglish
Pages (from-to)1447-1454
Number of pages8
JournalCancer Research
Volume39
Issue number5
StatePublished - Dec 1 1979
Externally publishedYes

Fingerprint

Steroid Receptors
Glucocorticoid Receptors
Androgen Receptors
Progesterone Receptors
Estrogen Receptors
Breast Neoplasms
Hormones
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Allegra, J. C., Lippman, M. E., Thompson, E. B., Simon, R., Barlock, A., Green, L., ... Aitken, S. C. (1979). Distribution, frequency, and quantitative analysis of estrogen, progesterone, androgen, and glucocorticoid receptors in human breast cancer. Cancer Research, 39(5), 1447-1454.

Distribution, frequency, and quantitative analysis of estrogen, progesterone, androgen, and glucocorticoid receptors in human breast cancer. / Allegra, J. C.; Lippman, Marc E; Thompson, E. B.; Simon, R.; Barlock, A.; Green, L.; Huff, K. K.; Do, H. M.; Aitken, S. C.

In: Cancer Research, Vol. 39, No. 5, 01.12.1979, p. 1447-1454.

Research output: Contribution to journalArticle

Allegra, JC, Lippman, ME, Thompson, EB, Simon, R, Barlock, A, Green, L, Huff, KK, Do, HM & Aitken, SC 1979, 'Distribution, frequency, and quantitative analysis of estrogen, progesterone, androgen, and glucocorticoid receptors in human breast cancer', Cancer Research, vol. 39, no. 5, pp. 1447-1454.
Allegra JC, Lippman ME, Thompson EB, Simon R, Barlock A, Green L et al. Distribution, frequency, and quantitative analysis of estrogen, progesterone, androgen, and glucocorticoid receptors in human breast cancer. Cancer Research. 1979 Dec 1;39(5):1447-1454.
Allegra, J. C. ; Lippman, Marc E ; Thompson, E. B. ; Simon, R. ; Barlock, A. ; Green, L. ; Huff, K. K. ; Do, H. M. ; Aitken, S. C. / Distribution, frequency, and quantitative analysis of estrogen, progesterone, androgen, and glucocorticoid receptors in human breast cancer. In: Cancer Research. 1979 ; Vol. 39, No. 5. pp. 1447-1454.
@article{cc141eb709494a67a1f255e7acd64b0a,
title = "Distribution, frequency, and quantitative analysis of estrogen, progesterone, androgen, and glucocorticoid receptors in human breast cancer",
abstract = "The distribution and frequency of steroid hormone receptors are described in 329 patients with breast cancer. The distribution of each of the steroid hormone receptors is unimodal with a progressive increase in the proportion of patients positive at lower receptor values. Receptor values expressed as fmol/mg cytoplasmic protein are well correlated with values expressed as fmol/mg breast tumor. Estrogen receptor was positive in 53{\%} of the patients; progesterone receptor was positive in 38{\%} of the patients; glucocorticoid receptor was positive in 52{\%} of the patients; and androgen receptor was positive in 31{\%} of the patients. The type of tissue assayed did not affect steroid hormone receptor positivity. For primary tumors, there was no correlation between steroid hormone receptor positivity and lcoation of the tumor in the breast, size of the tumor, or extent of the disease. Each of the steroid hormone receptors was positively associated with each of the other steroid homone receptors. Estrogen receptor was correlated with menopausal status and axillary nodal status, but these correlations did not exist for the other steroid hormone receptors. Estrogen receptor was not correlated with age after adjustment for menopausal status. The other steroid hormone receptors were not correlated with age.",
author = "Allegra, {J. C.} and Lippman, {Marc E} and Thompson, {E. B.} and R. Simon and A. Barlock and L. Green and Huff, {K. K.} and Do, {H. M.} and Aitken, {S. C.}",
year = "1979",
month = "12",
day = "1",
language = "English",
volume = "39",
pages = "1447--1454",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

TY - JOUR

T1 - Distribution, frequency, and quantitative analysis of estrogen, progesterone, androgen, and glucocorticoid receptors in human breast cancer

AU - Allegra, J. C.

AU - Lippman, Marc E

AU - Thompson, E. B.

AU - Simon, R.

AU - Barlock, A.

AU - Green, L.

AU - Huff, K. K.

AU - Do, H. M.

AU - Aitken, S. C.

PY - 1979/12/1

Y1 - 1979/12/1

N2 - The distribution and frequency of steroid hormone receptors are described in 329 patients with breast cancer. The distribution of each of the steroid hormone receptors is unimodal with a progressive increase in the proportion of patients positive at lower receptor values. Receptor values expressed as fmol/mg cytoplasmic protein are well correlated with values expressed as fmol/mg breast tumor. Estrogen receptor was positive in 53% of the patients; progesterone receptor was positive in 38% of the patients; glucocorticoid receptor was positive in 52% of the patients; and androgen receptor was positive in 31% of the patients. The type of tissue assayed did not affect steroid hormone receptor positivity. For primary tumors, there was no correlation between steroid hormone receptor positivity and lcoation of the tumor in the breast, size of the tumor, or extent of the disease. Each of the steroid hormone receptors was positively associated with each of the other steroid homone receptors. Estrogen receptor was correlated with menopausal status and axillary nodal status, but these correlations did not exist for the other steroid hormone receptors. Estrogen receptor was not correlated with age after adjustment for menopausal status. The other steroid hormone receptors were not correlated with age.

AB - The distribution and frequency of steroid hormone receptors are described in 329 patients with breast cancer. The distribution of each of the steroid hormone receptors is unimodal with a progressive increase in the proportion of patients positive at lower receptor values. Receptor values expressed as fmol/mg cytoplasmic protein are well correlated with values expressed as fmol/mg breast tumor. Estrogen receptor was positive in 53% of the patients; progesterone receptor was positive in 38% of the patients; glucocorticoid receptor was positive in 52% of the patients; and androgen receptor was positive in 31% of the patients. The type of tissue assayed did not affect steroid hormone receptor positivity. For primary tumors, there was no correlation between steroid hormone receptor positivity and lcoation of the tumor in the breast, size of the tumor, or extent of the disease. Each of the steroid hormone receptors was positively associated with each of the other steroid homone receptors. Estrogen receptor was correlated with menopausal status and axillary nodal status, but these correlations did not exist for the other steroid hormone receptors. Estrogen receptor was not correlated with age after adjustment for menopausal status. The other steroid hormone receptors were not correlated with age.

UR - http://www.scopus.com/inward/record.url?scp=0018772967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018772967&partnerID=8YFLogxK

M3 - Article

C2 - 427788

AN - SCOPUS:0018772967

VL - 39

SP - 1447

EP - 1454

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 5

ER -